Ablation of MCL1 expression by virally induced microRNA-29 reverses chemoresistance in human osteosarcomas

Osteosarcoma is a rare disease diagnosed as malignant bone tumor. It is generally refractory to chemotherapy, which contributes to its poor prognosis. The reversal of chemoresistance is a major clinical challenge to improve the prognostic outcome of osteosarcoma patients. We developed a tumor-specif...

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Detalles Bibliográficos
Autores principales: Osaki, Shuhei, Tazawa, Hiroshi, Hasei, Joe, Yamakawa, Yasuaki, Omori, Toshinori, Sugiu, Kazuhisa, Komatsubara, Tadashi, Fujiwara, Tomohiro, Sasaki, Tsuyoshi, Kunisada, Toshiyuki, Yoshida, Aki, Urata, Yasuo, Kagawa, Shunsuke, Ozaki, Toshifumi, Fujiwara, Toshiyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928055/
https://www.ncbi.nlm.nih.gov/pubmed/27356624
http://dx.doi.org/10.1038/srep28953

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