Systemic desensitization through TRPA1 channels by capsazepine and mustard oil - a novel strategy against inflammation and pain

We demonstrate a novel dual strategy against inflammation and pain through body-wide desensitization of nociceptors via TRPA1. Attenuation of experimental colitis by capsazepine (CPZ) has long been attributed to its antagonistic action on TRPV1 and associated inhibition of neurogenic inflammation. I...

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Detalles Bibliográficos
Autores principales: Kistner, Katrin, Siklosi, Norbert, Babes, Alexandru, Khalil, Mohammad, Selescu, Tudor, Zimmermann, Katharina, Wirtz, Stefan, Becker, Christoph, Neurath, Markus F., Reeh, Peter W., Engel, Matthias A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928060/
https://www.ncbi.nlm.nih.gov/pubmed/27356469
http://dx.doi.org/10.1038/srep28621

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