Mutation of DNA Polymerase β R137Q Results in Retarded Embryo Development Due to Impaired DNA Base Excision Repair in Mice

DNA polymerase β (Pol β), a key enzyme in the DNA base excision repair (BER) pathway, is pivotal in maintaining the integrity and stability of genomes. One Pol β mutation that has been identified in tumors, R137Q (arginine to glutamine substitution), has been shown to lower polymerase activity, and...

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Detalles Bibliográficos
Autores principales: Pan, Feiyan, Zhao, Jing, Zhou, Ting, Kuang, Zhihui, Dai, Huifang, Wu, Huan, Sun, Hongfang, Zhou, Xiaolong, Wu, Xuping, Hu, Zhigang, He, Lingfeng, Shen, Binghui, Guo, Zhigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928080/
https://www.ncbi.nlm.nih.gov/pubmed/27358192
http://dx.doi.org/10.1038/srep28614

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