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Negative selection maintains transcription factor binding motifs in human cancer

BACKGROUND: Somatic mutations in cancer cells affect various genomic elements disrupting important cell functions. In particular, mutations in DNA binding sites recognized by transcription factors can alter regulator binding affinities and, consequently, expression of target genes. A number of promo...

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Detalles Bibliográficos
Autores principales:	Vorontsov, Ilya E., Khimulya, Grigory, Lukianova, Elena N., Nikolaeva, Daria D., Eliseeva, Irina A., Kulakovskiy, Ivan V., Makeev, Vsevolod J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928157/ https://www.ncbi.nlm.nih.gov/pubmed/27356864 http://dx.doi.org/10.1186/s12864-016-2728-9

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