Multiple regulatory variants located in cell type-specific enhancers within the PKP2 locus form major risk and protective haplotypes for canine atopic dermatitis in German shepherd dogs

BACKGROUND: Canine atopic dermatitis (CAD) is a chronic inflammatory skin disease triggered by allergic reactions involving IgE antibodies directed towards environmental allergens. We previously identified a ~1.5 Mb locus on canine chromosome 27 associated with CAD in German shepherd dogs (GSDs). Fi...

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Detalles Bibliográficos
Autores principales: Tengvall, Katarina, Kozyrev, Sergey, Kierczak, Marcin, Bergvall, Kerstin, Farias, Fabiana H. G., Ardesjö-Lundgren, Brita, Olsson, Mia, Murén, Eva, Hagman, Ragnvi, Leeb, Tosso, Pielberg, Gerli, Hedhammar, Åke, Andersson, Göran, Lindblad-Toh, Kerstin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928279/
https://www.ncbi.nlm.nih.gov/pubmed/27357287
http://dx.doi.org/10.1186/s12863-016-0404-3

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