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Isolation of an imported subgenotype B5 strain of human enterovirus A71 in Chongqing City, China, 2014

BACKGROUND: Enterovirus A71 (EV-A71) is the main pathogen responsible for large outbreaks of hand, foot, and mouth disease (HFMD) in mainland China, and the dominant EV-A71 strains belong to subgenotype C4. To date, only one imported subgenotype B5 of EV-A71 has been reported in Xiamen City Fujian P...

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Autores principales: Yang, Qian, Zhang, Yong, Yan, Dongmei, Zhu, Shuangli, Wang, Dongyan, Ji, Tianjiao, Huang, Wei, An, Hongqiu, Xu, Wenbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928301/
https://www.ncbi.nlm.nih.gov/pubmed/27357279
http://dx.doi.org/10.1186/s12985-016-0571-x
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author Yang, Qian
Zhang, Yong
Yan, Dongmei
Zhu, Shuangli
Wang, Dongyan
Ji, Tianjiao
Huang, Wei
An, Hongqiu
Xu, Wenbo
author_facet Yang, Qian
Zhang, Yong
Yan, Dongmei
Zhu, Shuangli
Wang, Dongyan
Ji, Tianjiao
Huang, Wei
An, Hongqiu
Xu, Wenbo
author_sort Yang, Qian
collection PubMed
description BACKGROUND: Enterovirus A71 (EV-A71) is the main pathogen responsible for large outbreaks of hand, foot, and mouth disease (HFMD) in mainland China, and the dominant EV-A71 strains belong to subgenotype C4. To date, only one imported subgenotype B5 of EV-A71 has been reported in Xiamen City Fujian Province, 2009. RESULTS: Here, we report on another imported subgenotype B5 of EV-A71 isolated from a HFMD patient in Chongqing City in 2014 (strain CQ2014-86/CQ/CHN/2014, hereafter refer as CQ2014-86). The VP1 coding sequence and the whole genome sequence revealed that strain CQ2014-86 shares the high nucleotide identity with Vietnamese strains isolated in 2011–2013, suggesting that strain CQ2014-86 may have been imported from Vietnam. In the 5’UTR, P2 and P3 regions, recombination events were found between strain CQ2014-86 and other EV-A, such as coxsackievirus A4 (CV-A4), CV-A5, CV-A14 and CV-A16. CONCLUSIONS: This is the second report on importation of subgenotype B5 of EV-A71 in China, implying that we need to pay more attention to the importation of different subgenotypes of EV-A71.
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spelling pubmed-49283012016-06-30 Isolation of an imported subgenotype B5 strain of human enterovirus A71 in Chongqing City, China, 2014 Yang, Qian Zhang, Yong Yan, Dongmei Zhu, Shuangli Wang, Dongyan Ji, Tianjiao Huang, Wei An, Hongqiu Xu, Wenbo Virol J Short Report BACKGROUND: Enterovirus A71 (EV-A71) is the main pathogen responsible for large outbreaks of hand, foot, and mouth disease (HFMD) in mainland China, and the dominant EV-A71 strains belong to subgenotype C4. To date, only one imported subgenotype B5 of EV-A71 has been reported in Xiamen City Fujian Province, 2009. RESULTS: Here, we report on another imported subgenotype B5 of EV-A71 isolated from a HFMD patient in Chongqing City in 2014 (strain CQ2014-86/CQ/CHN/2014, hereafter refer as CQ2014-86). The VP1 coding sequence and the whole genome sequence revealed that strain CQ2014-86 shares the high nucleotide identity with Vietnamese strains isolated in 2011–2013, suggesting that strain CQ2014-86 may have been imported from Vietnam. In the 5’UTR, P2 and P3 regions, recombination events were found between strain CQ2014-86 and other EV-A, such as coxsackievirus A4 (CV-A4), CV-A5, CV-A14 and CV-A16. CONCLUSIONS: This is the second report on importation of subgenotype B5 of EV-A71 in China, implying that we need to pay more attention to the importation of different subgenotypes of EV-A71. BioMed Central 2016-06-29 /pmc/articles/PMC4928301/ /pubmed/27357279 http://dx.doi.org/10.1186/s12985-016-0571-x Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Short Report
Yang, Qian
Zhang, Yong
Yan, Dongmei
Zhu, Shuangli
Wang, Dongyan
Ji, Tianjiao
Huang, Wei
An, Hongqiu
Xu, Wenbo
Isolation of an imported subgenotype B5 strain of human enterovirus A71 in Chongqing City, China, 2014
title Isolation of an imported subgenotype B5 strain of human enterovirus A71 in Chongqing City, China, 2014
title_full Isolation of an imported subgenotype B5 strain of human enterovirus A71 in Chongqing City, China, 2014
title_fullStr Isolation of an imported subgenotype B5 strain of human enterovirus A71 in Chongqing City, China, 2014
title_full_unstemmed Isolation of an imported subgenotype B5 strain of human enterovirus A71 in Chongqing City, China, 2014
title_short Isolation of an imported subgenotype B5 strain of human enterovirus A71 in Chongqing City, China, 2014
title_sort isolation of an imported subgenotype b5 strain of human enterovirus a71 in chongqing city, china, 2014
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928301/
https://www.ncbi.nlm.nih.gov/pubmed/27357279
http://dx.doi.org/10.1186/s12985-016-0571-x
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