Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment

BACKGROUND: Neurons are highly polarized cells in which asymmetric axonal-dendritic distribution of proteins is crucial for neuronal function. Loss of polarized distribution of the axonal protein tau is an early sign of Alzheimer’s disease (AD) and other neurodegenerative disorders. The cytoskeletal...

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Detalles Bibliográficos
Autores principales: Sohn, Peter Dongmin, Tracy, Tara E., Son, Hye-In, Zhou, Yungui, Leite, Renata E. P., Miller, Bruce L., Seeley, William W., Grinberg, Lea T., Gan, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928318/
https://www.ncbi.nlm.nih.gov/pubmed/27356871
http://dx.doi.org/10.1186/s13024-016-0109-0

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