VPAC1 receptor (Vipr1)-deficient mice exhibit ameliorated experimental autoimmune encephalomyelitis, with specific deficits in the effector stage

BACKGROUND: Vasoactive intestinal peptide (VIP) and pituitary adenylyl cyclase-activating polypeptide (PACAP) are two highly homologous neuropeptides. In vitro and ex vivo experiments repeatedly demonstrate that these peptides exert pronounced immunomodulatory (primarily anti-inflammatory) actions w...

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Detalles Bibliográficos
Autores principales: Abad, Catalina, Jayaram, Bhavaani, Becquet, Laurine, Wang, Yuki, O’Dorisio, M Sue, Waschek, James A., Tan, Yossan-Var
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928347/
https://www.ncbi.nlm.nih.gov/pubmed/27357191
http://dx.doi.org/10.1186/s12974-016-0626-3

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