Update on the challenges and recent advances in cancer immunotherapy

This overview provides an analysis of some of the immunotherapies currently in use and under investigation, with a special focus on the tumor microenvironment, which we believe is a major factor responsible for the general failure of immunotherapy to date. It is our expectation that combining immuno...

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Detalles Bibliográficos
Autores principales: Baronzio, Gianfranco, Parmar, Gurdev, Shubina, Irina ZH, Cassutti, Valter, Giuli, Sergio, Ballerini, Marco, Kiselevsky, Mikhail
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928368/
https://www.ncbi.nlm.nih.gov/pubmed/27471687
http://dx.doi.org/10.2147/ITT.S30818
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author Baronzio, Gianfranco
Parmar, Gurdev
Shubina, Irina ZH
Cassutti, Valter
Giuli, Sergio
Ballerini, Marco
Kiselevsky, Mikhail
author_facet Baronzio, Gianfranco
Parmar, Gurdev
Shubina, Irina ZH
Cassutti, Valter
Giuli, Sergio
Ballerini, Marco
Kiselevsky, Mikhail
author_sort Baronzio, Gianfranco
collection PubMed
description This overview provides an analysis of some of the immunotherapies currently in use and under investigation, with a special focus on the tumor microenvironment, which we believe is a major factor responsible for the general failure of immunotherapy to date. It is our expectation that combining immunotherapy with methods of altering the tumor microenvironment and targeting regulatory T cells and myeloid cells will yield favorable results.
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spelling pubmed-49283682016-07-28 Update on the challenges and recent advances in cancer immunotherapy Baronzio, Gianfranco Parmar, Gurdev Shubina, Irina ZH Cassutti, Valter Giuli, Sergio Ballerini, Marco Kiselevsky, Mikhail Immunotargets Ther Review This overview provides an analysis of some of the immunotherapies currently in use and under investigation, with a special focus on the tumor microenvironment, which we believe is a major factor responsible for the general failure of immunotherapy to date. It is our expectation that combining immunotherapy with methods of altering the tumor microenvironment and targeting regulatory T cells and myeloid cells will yield favorable results. Dove Medical Press 2013-06-15 /pmc/articles/PMC4928368/ /pubmed/27471687 http://dx.doi.org/10.2147/ITT.S30818 Text en © 2013 Baronzio et al, publisher and licensee Dove Medical Press Ltd This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Review
Baronzio, Gianfranco
Parmar, Gurdev
Shubina, Irina ZH
Cassutti, Valter
Giuli, Sergio
Ballerini, Marco
Kiselevsky, Mikhail
Update on the challenges and recent advances in cancer immunotherapy
title Update on the challenges and recent advances in cancer immunotherapy
title_full Update on the challenges and recent advances in cancer immunotherapy
title_fullStr Update on the challenges and recent advances in cancer immunotherapy
title_full_unstemmed Update on the challenges and recent advances in cancer immunotherapy
title_short Update on the challenges and recent advances in cancer immunotherapy
title_sort update on the challenges and recent advances in cancer immunotherapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928368/
https://www.ncbi.nlm.nih.gov/pubmed/27471687
http://dx.doi.org/10.2147/ITT.S30818
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