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Collecting reliable clades using the Greedy Strict Consensus Merger
Supertree methods combine a set of phylogenetic trees into a single supertree. Similar to supermatrix methods, these methods provide a way to reconstruct larger parts of the Tree of Life, potentially evading the computational complexity of phylogenetic inference methods such as maximum likelihood. T...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PeerJ Inc.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928488/ https://www.ncbi.nlm.nih.gov/pubmed/27375971 http://dx.doi.org/10.7717/peerj.2172 |
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author | Fleischauer, Markus Böcker, Sebastian |
author_facet | Fleischauer, Markus Böcker, Sebastian |
author_sort | Fleischauer, Markus |
collection | PubMed |
description | Supertree methods combine a set of phylogenetic trees into a single supertree. Similar to supermatrix methods, these methods provide a way to reconstruct larger parts of the Tree of Life, potentially evading the computational complexity of phylogenetic inference methods such as maximum likelihood. The supertree problem can be formalized in different ways, to cope with contradictory information in the input. Many supertree methods have been developed. Some of them solve NP-hard optimization problems like the well-known Matrix Representation with Parsimony, while others have polynomial worst-case running time but work in a greedy fashion (FlipCut). Both can profit from a set of clades that are already known to be part of the supertree. The Superfine approach shows how the Greedy Strict Consensus Merger (GSCM) can be used as preprocessing to find these clades. We introduce different scoring functions for the GSCM, a randomization, as well as a combination thereof to improve the GSCM to find more clades. This helps, in turn, to improve the resolution of the GSCM supertree. We find this modifications to increase the number of true positive clades by 18% compared to the currently used Overlap scoring. |
format | Online Article Text |
id | pubmed-4928488 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | PeerJ Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-49284882016-07-01 Collecting reliable clades using the Greedy Strict Consensus Merger Fleischauer, Markus Böcker, Sebastian PeerJ Bioinformatics Supertree methods combine a set of phylogenetic trees into a single supertree. Similar to supermatrix methods, these methods provide a way to reconstruct larger parts of the Tree of Life, potentially evading the computational complexity of phylogenetic inference methods such as maximum likelihood. The supertree problem can be formalized in different ways, to cope with contradictory information in the input. Many supertree methods have been developed. Some of them solve NP-hard optimization problems like the well-known Matrix Representation with Parsimony, while others have polynomial worst-case running time but work in a greedy fashion (FlipCut). Both can profit from a set of clades that are already known to be part of the supertree. The Superfine approach shows how the Greedy Strict Consensus Merger (GSCM) can be used as preprocessing to find these clades. We introduce different scoring functions for the GSCM, a randomization, as well as a combination thereof to improve the GSCM to find more clades. This helps, in turn, to improve the resolution of the GSCM supertree. We find this modifications to increase the number of true positive clades by 18% compared to the currently used Overlap scoring. PeerJ Inc. 2016-06-28 /pmc/articles/PMC4928488/ /pubmed/27375971 http://dx.doi.org/10.7717/peerj.2172 Text en ©2016 Fleischauer and Böcker http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited. |
spellingShingle | Bioinformatics Fleischauer, Markus Böcker, Sebastian Collecting reliable clades using the Greedy Strict Consensus Merger |
title | Collecting reliable clades using the Greedy Strict Consensus Merger |
title_full | Collecting reliable clades using the Greedy Strict Consensus Merger |
title_fullStr | Collecting reliable clades using the Greedy Strict Consensus Merger |
title_full_unstemmed | Collecting reliable clades using the Greedy Strict Consensus Merger |
title_short | Collecting reliable clades using the Greedy Strict Consensus Merger |
title_sort | collecting reliable clades using the greedy strict consensus merger |
topic | Bioinformatics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928488/ https://www.ncbi.nlm.nih.gov/pubmed/27375971 http://dx.doi.org/10.7717/peerj.2172 |
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