LXY6090 – a novel manassantin A derivative – limits breast cancer growth through hypoxia-inducible factor-1 inhibition

Hypoxia-inducible factor-1 (HIF-1) represents a novel antitumor target owing to its involvement in vital processes considered hallmarks of cancer phenotypes. Manassantin A (MA) derived from Saururus cernuus has been reported as a selective HIF-1 inhibitor. Herein, the structure of MA was optimized t...

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Detalles Bibliográficos
Autores principales: Lai, Fangfang, Liu, Qian, Liu, Xiaoyu, Ji, Ming, Xie, Ping, Chen, Xiaoguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928675/
https://www.ncbi.nlm.nih.gov/pubmed/27445487
http://dx.doi.org/10.2147/OTT.S106925

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928675/
https://www.ncbi.nlm.nih.gov/pubmed/27445487
http://dx.doi.org/10.2147/OTT.S106925

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