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Preserving Fertility in Children and Adolescents with Cancer

In the face of excellent survival rates for pediatric and adolescent cancer, preserving the opportunity to have biological children is an important component of long term quality of life. Yet, modern chemotherapeutic regimens continue to pose a threat to fertility. The only fertility preservation me...

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Detalles Bibliográficos
Autor principal: Levine, Jennifer M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928722/
https://www.ncbi.nlm.nih.gov/pubmed/27417474
http://dx.doi.org/10.3390/children1020166
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author Levine, Jennifer M.
author_facet Levine, Jennifer M.
author_sort Levine, Jennifer M.
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description In the face of excellent survival rates for pediatric and adolescent cancer, preserving the opportunity to have biological children is an important component of long term quality of life. Yet, modern chemotherapeutic regimens continue to pose a threat to fertility. The only fertility preservation methods available to pre-pubertal children of both genders is cryopreservation of gonadal tissue, a highly experimental intervention, or shielding/re-location of reproductive tissue in the setting of radiation. These techniques are available in the post pubertal population as well, but post pubertal patients also have the option for cryopreservation of gametes, a process that is much simpler in males than females. For this reason, prior to the initiation of therapy, sperm banking should be considered standard of care for males, while consideration of embryo or oocyte cryopreservation should be limited to those females at risk of developing ovarian failure. Attention to reproductive health and fertility preservation should continue after the completion of therapy. Establishing programs that streamline access to current fertility preservation techniques will assist in ensuring that all eligible patients can avail themselves of current options.
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spelling pubmed-49287222016-07-12 Preserving Fertility in Children and Adolescents with Cancer Levine, Jennifer M. Children (Basel) Review In the face of excellent survival rates for pediatric and adolescent cancer, preserving the opportunity to have biological children is an important component of long term quality of life. Yet, modern chemotherapeutic regimens continue to pose a threat to fertility. The only fertility preservation methods available to pre-pubertal children of both genders is cryopreservation of gonadal tissue, a highly experimental intervention, or shielding/re-location of reproductive tissue in the setting of radiation. These techniques are available in the post pubertal population as well, but post pubertal patients also have the option for cryopreservation of gametes, a process that is much simpler in males than females. For this reason, prior to the initiation of therapy, sperm banking should be considered standard of care for males, while consideration of embryo or oocyte cryopreservation should be limited to those females at risk of developing ovarian failure. Attention to reproductive health and fertility preservation should continue after the completion of therapy. Establishing programs that streamline access to current fertility preservation techniques will assist in ensuring that all eligible patients can avail themselves of current options. MDPI 2014-08-26 /pmc/articles/PMC4928722/ /pubmed/27417474 http://dx.doi.org/10.3390/children1020166 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Levine, Jennifer M.
Preserving Fertility in Children and Adolescents with Cancer
title Preserving Fertility in Children and Adolescents with Cancer
title_full Preserving Fertility in Children and Adolescents with Cancer
title_fullStr Preserving Fertility in Children and Adolescents with Cancer
title_full_unstemmed Preserving Fertility in Children and Adolescents with Cancer
title_short Preserving Fertility in Children and Adolescents with Cancer
title_sort preserving fertility in children and adolescents with cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928722/
https://www.ncbi.nlm.nih.gov/pubmed/27417474
http://dx.doi.org/10.3390/children1020166
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