Cargando…

Young Age at Diagnosis of Type 1 Diabetes Is Associated with the Development of Celiac Disease—Associated Antibodies in Children Living in Newfoundland and Labrador, Canada

Objectives: The objectives of this study were to establish the prevalence of positive antibodies to endomysium (EMA) and tissue transglutaminase (tTG) in children with type 1 diabetes living in Newfoundland and Labrador (NL), and to examine clinical features associated with positive antibodies. Meth...

Descripción completa

Detalles Bibliográficos
Autores principales: Pall, Harpreet, Newhook, Leigh A., Aaron, Hillary, Curtis, Joseph, Randell, Ed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928772/
https://www.ncbi.nlm.nih.gov/pubmed/27417372
http://dx.doi.org/10.3390/children2040403
_version_ 1782440490350673920
author Pall, Harpreet
Newhook, Leigh A.
Aaron, Hillary
Curtis, Joseph
Randell, Ed
author_facet Pall, Harpreet
Newhook, Leigh A.
Aaron, Hillary
Curtis, Joseph
Randell, Ed
author_sort Pall, Harpreet
collection PubMed
description Objectives: The objectives of this study were to establish the prevalence of positive antibodies to endomysium (EMA) and tissue transglutaminase (tTG) in children with type 1 diabetes living in Newfoundland and Labrador (NL), and to examine clinical features associated with positive antibodies. Methods: Patients were recruited from the pediatric diabetes clinic. One hundred sixty-seven children with type 1 diabetes from the 280 children followed at the clinic were prospectively screened for celiac disease using EMA and tTG. The variables of Irish descent, age at onset of diabetes, duration of diabetes, sex, family history of celiac disease, hemoglobin A1C (A1C), ferritin, gastrointestinal symptoms, and body mass index were compiled for all patients. The group of patients with positive antibodies to EMA and/or tTG was compared to the group with negative antibodies. Results: The prevalence of patients with positive antibodies to EMA and/or tTG was 16.8% (n = 28). One patient had also been previously diagnosed with symptomatic celiac disease. The two statistically significant variables with positive antibodies were an earlier age at onset of diabetes (Mann-Whitney U two-tailed test: mean difference 3.2 years, 95% CI 1.7–4.8 years, p < 0.0001) and longer duration of diabetes (Mann-Whitney U two-tailed test: mean difference 2.9 years, 95% CI 1.3–4.4 years, p < 0.0001). Irish descent was associated with positive antibodies but did not reach statistical significance. On logistic regression analysis performed with these three variables together, only age at onset of diabetes remained significant. Conclusions: There is a high prevalence of celiac disease-associated antibodies in children living in NL with type 1 diabetes. Unlike other clinical features, an earlier age at onset of diabetes was predictive for positive antibodies. As the majority of children with positive antibodies did not have signs or symptoms of celiac disease, routine screening for celiac disease in type 1 diabetes is recommended.
format Online
Article
Text
id pubmed-4928772
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-49287722016-07-12 Young Age at Diagnosis of Type 1 Diabetes Is Associated with the Development of Celiac Disease—Associated Antibodies in Children Living in Newfoundland and Labrador, Canada Pall, Harpreet Newhook, Leigh A. Aaron, Hillary Curtis, Joseph Randell, Ed Children (Basel) Article Objectives: The objectives of this study were to establish the prevalence of positive antibodies to endomysium (EMA) and tissue transglutaminase (tTG) in children with type 1 diabetes living in Newfoundland and Labrador (NL), and to examine clinical features associated with positive antibodies. Methods: Patients were recruited from the pediatric diabetes clinic. One hundred sixty-seven children with type 1 diabetes from the 280 children followed at the clinic were prospectively screened for celiac disease using EMA and tTG. The variables of Irish descent, age at onset of diabetes, duration of diabetes, sex, family history of celiac disease, hemoglobin A1C (A1C), ferritin, gastrointestinal symptoms, and body mass index were compiled for all patients. The group of patients with positive antibodies to EMA and/or tTG was compared to the group with negative antibodies. Results: The prevalence of patients with positive antibodies to EMA and/or tTG was 16.8% (n = 28). One patient had also been previously diagnosed with symptomatic celiac disease. The two statistically significant variables with positive antibodies were an earlier age at onset of diabetes (Mann-Whitney U two-tailed test: mean difference 3.2 years, 95% CI 1.7–4.8 years, p < 0.0001) and longer duration of diabetes (Mann-Whitney U two-tailed test: mean difference 2.9 years, 95% CI 1.3–4.4 years, p < 0.0001). Irish descent was associated with positive antibodies but did not reach statistical significance. On logistic regression analysis performed with these three variables together, only age at onset of diabetes remained significant. Conclusions: There is a high prevalence of celiac disease-associated antibodies in children living in NL with type 1 diabetes. Unlike other clinical features, an earlier age at onset of diabetes was predictive for positive antibodies. As the majority of children with positive antibodies did not have signs or symptoms of celiac disease, routine screening for celiac disease in type 1 diabetes is recommended. MDPI 2015-10-14 /pmc/articles/PMC4928772/ /pubmed/27417372 http://dx.doi.org/10.3390/children2040403 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pall, Harpreet
Newhook, Leigh A.
Aaron, Hillary
Curtis, Joseph
Randell, Ed
Young Age at Diagnosis of Type 1 Diabetes Is Associated with the Development of Celiac Disease—Associated Antibodies in Children Living in Newfoundland and Labrador, Canada
title Young Age at Diagnosis of Type 1 Diabetes Is Associated with the Development of Celiac Disease—Associated Antibodies in Children Living in Newfoundland and Labrador, Canada
title_full Young Age at Diagnosis of Type 1 Diabetes Is Associated with the Development of Celiac Disease—Associated Antibodies in Children Living in Newfoundland and Labrador, Canada
title_fullStr Young Age at Diagnosis of Type 1 Diabetes Is Associated with the Development of Celiac Disease—Associated Antibodies in Children Living in Newfoundland and Labrador, Canada
title_full_unstemmed Young Age at Diagnosis of Type 1 Diabetes Is Associated with the Development of Celiac Disease—Associated Antibodies in Children Living in Newfoundland and Labrador, Canada
title_short Young Age at Diagnosis of Type 1 Diabetes Is Associated with the Development of Celiac Disease—Associated Antibodies in Children Living in Newfoundland and Labrador, Canada
title_sort young age at diagnosis of type 1 diabetes is associated with the development of celiac disease—associated antibodies in children living in newfoundland and labrador, canada
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928772/
https://www.ncbi.nlm.nih.gov/pubmed/27417372
http://dx.doi.org/10.3390/children2040403
work_keys_str_mv AT pallharpreet youngageatdiagnosisoftype1diabetesisassociatedwiththedevelopmentofceliacdiseaseassociatedantibodiesinchildrenlivinginnewfoundlandandlabradorcanada
AT newhookleigha youngageatdiagnosisoftype1diabetesisassociatedwiththedevelopmentofceliacdiseaseassociatedantibodiesinchildrenlivinginnewfoundlandandlabradorcanada
AT aaronhillary youngageatdiagnosisoftype1diabetesisassociatedwiththedevelopmentofceliacdiseaseassociatedantibodiesinchildrenlivinginnewfoundlandandlabradorcanada
AT curtisjoseph youngageatdiagnosisoftype1diabetesisassociatedwiththedevelopmentofceliacdiseaseassociatedantibodiesinchildrenlivinginnewfoundlandandlabradorcanada
AT randelled youngageatdiagnosisoftype1diabetesisassociatedwiththedevelopmentofceliacdiseaseassociatedantibodiesinchildrenlivinginnewfoundlandandlabradorcanada