Encapsulation-free controlled release: Electrostatic adsorption eliminates the need for protein encapsulation in PLGA nanoparticles

Encapsulation of therapeutic molecules within polymer particles is a well-established method for achieving controlled release, yet challenges such as low loading, poor encapsulation efficiency, and loss of protein activity limit clinical translation. Despite this, the paradigm for the use of polymer...

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Detalles Bibliográficos
Autores principales: Pakulska, Malgosia M., Elliott Donaghue, Irja, Obermeyer, Jaclyn M., Tuladhar, Anup, McLaughlin, Christopher K., Shendruk, Tyler N., Shoichet, Molly S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928928/
https://www.ncbi.nlm.nih.gov/pubmed/27386554
http://dx.doi.org/10.1126/sciadv.1600519

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