Cargando…

Inferring Strain Mixture within Clinical Plasmodium falciparum Isolates from Genomic Sequence Data

We present a rigorous statistical model that infers the structure of P. falciparum mixtures—including the number of strains present, their proportion within the samples, and the amount of unexplained mixture—using whole genome sequence (WGS) data. Applied to simulation data, artificial laboratory mi...

Descripción completa

Detalles Bibliográficos
Autores principales:	O’Brien, John D., Iqbal, Zamin, Wendler, Jason, Amenga-Etego, Lucas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928962/ https://www.ncbi.nlm.nih.gov/pubmed/27362949 http://dx.doi.org/10.1371/journal.pcbi.1004824

Ejemplares similares

Approaches to estimating inbreeding coefficients in clinical isolates of Plasmodium falciparum from genomic sequence data
por: O’Brien, John D., et al.
Publicado: (2016)

A Bayesian Approach to Inferring the Phylogenetic Structure of Communities from Metagenomic Data
por: O’Brien, John D., et al.
Publicado: (2014)

Genomic analysis reveals independent evolution of Plasmodium falciparum populations in Ethiopia
por: Abera, Deriba, et al.
Publicado: (2021)

Prevalence of chloroquine and antifolate drug resistance alleles in Plasmodium falciparum clinical isolates from three areas in Ghana
por: Abugri, James, et al.
Publicado: (2018)

Comparative Susceptibility of Plasmodium ovale and Plasmodium falciparum Field Isolates to Reference and Lead Candidate Antimalarial Drugs in Ghana
por: Aniweh, Yaw, et al.
Publicado: (2023)

Co-infection of Plasmodium falciparum and Schistosoma mansoni is associated with anaemia
por: Dassah, Sylvester Donne, et al.
Publicado: (2023)

Population genetic analysis of the Plasmodium falciparum circumsporozoite protein in two distinct ecological regions in Ghana
por: Amegashie, Elikplim A., et al.
Publicado: (2020)

Plasmodium falciparum Malaria Parasites in Ghana Show Signatures of Balancing Selection at Artemisinin Resistance Predisposing Background Genes
por: Tandoh, Kwesi Z, et al.
Publicado: (2021)

Temporal evolution of sulfadoxine-pyrimethamine resistance genotypes and genetic diversity in response to a decade of increased interventions against Plasmodium falciparum in northern Ghana
por: Amenga-Etego, Lucas N., et al.
Publicado: (2021)

The biology of unconventional invasion of Duffy-negative reticulocytes by Plasmodium vivax and its implication in malaria epidemiology and public health
por: Golassa, Lemu, et al.
Publicado: (2020)

Whole genome sequencing of Plasmodium falciparum from dried blood spots using selective whole genome amplification
por: Oyola, Samuel O., et al.
Publicado: (2016)

Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing
por: Manske, Magnus, et al.
Publicado: (2012)

A cross strain Plasmodium falciparum microarray optimized for the transcriptome analysis of Plasmodium falciparum patient derived isolates
por: Subudhi, Amit Kumar, et al.
Publicado: (2016)

The global transcriptome of Plasmodium falciparum mid-stage gametocytes (stages II–IV) appears largely conserved and gametocyte-specific gene expression patterns vary in clinical isolates
por: Kengne-Ouafo, Jonas A., et al.
Publicado: (2023)

Drug resistance and vaccine target surveillance of Plasmodium falciparum using nanopore sequencing in Ghana
por: Girgis, Sophia T., et al.
Publicado: (2023)

Recent increase in low complexity polygenomic infections and sialic acid-independent invasion pathways in Plasmodium falciparum from Western Gambia
por: Nganyewo, Nora Nghochuzie, et al.
Publicado: (2023)

In silico characterisation of putative Plasmodium falciparum vaccine candidates in African malaria populations
por: Ajibola, O., et al.
Publicado: (2021)

Indels, structural variation, and recombination drive genomic diversity in Plasmodium falciparum
por: Miles, Alistair, et al.
Publicado: (2016)

Mitochondrial genome sequence diversity of Indian Plasmodium falciparum isolates
por: Tyagi, Suchi, et al.
Publicado: (2014)

Pfatp6 molecular profile of Plasmodium falciparum isolates in the western Brazilian Amazon
por: Brasil, Larissa W, et al.
Publicado: (2012)

DNA Sequence Polymorphism of the Lactate Dehydrogenase Genefrom Iranian Plasmodium vivax and Plasmodium falciparum Isolates
por: GETACHER FELEKE, Daniel, et al.
Publicado: (2015)

Whole Mitochondrial Genome Sequence of an Indian Plasmodium falciparum Field Isolate
por: Tyagi, Suchi, et al.
Publicado: (2014)

Age-specific patterns of DBLα var diversity can explain why residents of high malaria transmission areas remain susceptible to Plasmodium falciparum blood stage infection throughout life
por: Ruybal-Pesántez, Shazia, et al.
Publicado: (2022)

Characterization of Within-Host Plasmodium falciparum Diversity Using Next-Generation Sequence Data
por: Auburn, Sarah, et al.
Publicado: (2012)

Analytic optimization of Plasmodium falciparum marker gene haplotype recovery from amplicon deep sequencing of complex mixtures
por: Lapp, Zena, et al.
Publicado: (2023)

Drug resistance of Plasmodium falciparum and Plasmodium vivax isolates in Indonesia
por: Rahmasari, Farindira Vesti, et al.
Publicado: (2022)

Amplicon deep sequencing of kelch13 in Plasmodium falciparum isolates from Senegal
por: Gaye, Amy, et al.
Publicado: (2020)

Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia
por: Miotto, Olivo, et al.
Publicado: (2013)

Genetic affinities of an eradicated European Plasmodium falciparum strain
por: de-Dios, Toni, et al.
Publicado: (2019)

Plasmodium falciparum population structure inferred by msp1 amplicon sequencing of parasites collected from febrile patients in Kenya
por: Andika, Brian, et al.
Publicado: (2023)

Development of Cooperative Primer-Based Real-Time PCR Assays for the Detection of Plasmodium malariae and Plasmodium ovale
por: Ansah, Felix, et al.
Publicado: (2021)

Increased Polymorphism Near Low-Complexity Sequences across the Genomes of Plasmodium falciparum Isolates
por: Haerty, Wilfried, et al.
Publicado: (2011)

Pooled-DNA sequencing identifies genomic regions of selection in Nigerian isolates of Plasmodium falciparum
por: Oyebola, Kolapo M., et al.
Publicado: (2017)

Host-mediated selection impacts the diversity of Plasmodium falciparum antigens within infections
por: Early, Angela M., et al.
Publicado: (2018)

Genetic diversity of Plasmodium vivax and Plasmodium falciparum lactate dehydrogenases in Myanmar isolates
por: Lee, Jinyoung, et al.
Publicado: (2020)

Genetic Diversity of Plasmodium falciparum Field Isolates in Central Sudan Inferred by PCR Genotyping of Merozoite Surface Protein 1 and 2
por: Hamid, Muzamil M Abdel, et al.
Publicado: (2013)

A Genome Wide Association Study of Plasmodium falciparum Susceptibility to 22 Antimalarial Drugs in Kenya
por: Wendler, Jason P., et al.
Publicado: (2014)

Strain variation in early innate cytokine induction by Plasmodium falciparum
por: CORRIGAN, R A, et al.
Publicado: (2010)

Antifolate Agents Against Wild and Mutant Strains of Plasmodium falciparum
por: Shaikh, M. S., et al.
Publicado: (2014)

Functional Analysis of Sirtuin Genes in Multiple Plasmodium falciparum Strains
por: Merrick, Catherine J., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_fsnhbhdogbp5bs7sfg3i52qjsi