Structural basis for regulation of human calcium-sensing receptor by magnesium ions and an unexpected tryptophan derivative co-agonist

Ca(2+)-sensing receptors (CaSRs) modulate calcium and magnesium homeostasis and many (patho)physiological processes by responding to extracellular stimuli, including divalent cations and amino acids. We report the first crystal structure of the extracellular domain (ECD) of human CaSR bound with Mg(...

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Detalles Bibliográficos
Autores principales: Zhang, Chen, Zhang, Tuo, Zou, Juan, Miller, Cassandra Lynn, Gorkhali, Rakshya, Yang, Jeong-Yeh, Schilmiller, Anthony, Wang, Shuo, Huang, Kenneth, Brown, Edward M., Moremen, Kelley W., Hu, Jian, Yang, Jenny J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928972/
https://www.ncbi.nlm.nih.gov/pubmed/27386547
http://dx.doi.org/10.1126/sciadv.1600241

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