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Cell-specific synaptic plasticity induced by network oscillations

Gamma rhythms are known to contribute to the process of memory encoding. However, little is known about the underlying mechanisms at the molecular, cellular and network levels. Using local field potential recording in awake behaving mice and concomitant field potential and whole-cell recordings in s...

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Autores principales: Zarnadze, Shota, Bäuerle, Peter, Santos-Torres, Julio, Böhm, Claudia, Schmitz, Dietmar, Geiger, Jörg RP, Dugladze, Tamar, Gloveli, Tengis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929000/
https://www.ncbi.nlm.nih.gov/pubmed/27218453
http://dx.doi.org/10.7554/eLife.14912
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author Zarnadze, Shota
Bäuerle, Peter
Santos-Torres, Julio
Böhm, Claudia
Schmitz, Dietmar
Geiger, Jörg RP
Dugladze, Tamar
Gloveli, Tengis
author_facet Zarnadze, Shota
Bäuerle, Peter
Santos-Torres, Julio
Böhm, Claudia
Schmitz, Dietmar
Geiger, Jörg RP
Dugladze, Tamar
Gloveli, Tengis
author_sort Zarnadze, Shota
collection PubMed
description Gamma rhythms are known to contribute to the process of memory encoding. However, little is known about the underlying mechanisms at the molecular, cellular and network levels. Using local field potential recording in awake behaving mice and concomitant field potential and whole-cell recordings in slice preparations we found that gamma rhythms lead to activity-dependent modification of hippocampal networks, including alterations in sharp wave-ripple complexes. Network plasticity, expressed as long-lasting increases in sharp wave-associated synaptic currents, exhibits enhanced excitatory synaptic strength in pyramidal cells that is induced postsynaptically and depends on metabotropic glutamate receptor-5 activation. In sharp contrast, alteration of inhibitory synaptic strength is independent of postsynaptic activation and less pronounced. Further, we found a cell type-specific, directionally biased synaptic plasticity of two major types of GABAergic cells, parvalbumin- and cholecystokinin-expressing interneurons. Thus, we propose that gamma frequency oscillations represent a network state that introduces long-lasting synaptic plasticity in a cell-specific manner. DOI: http://dx.doi.org/10.7554/eLife.14912.001
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spelling pubmed-49290002016-07-05 Cell-specific synaptic plasticity induced by network oscillations Zarnadze, Shota Bäuerle, Peter Santos-Torres, Julio Böhm, Claudia Schmitz, Dietmar Geiger, Jörg RP Dugladze, Tamar Gloveli, Tengis eLife Neuroscience Gamma rhythms are known to contribute to the process of memory encoding. However, little is known about the underlying mechanisms at the molecular, cellular and network levels. Using local field potential recording in awake behaving mice and concomitant field potential and whole-cell recordings in slice preparations we found that gamma rhythms lead to activity-dependent modification of hippocampal networks, including alterations in sharp wave-ripple complexes. Network plasticity, expressed as long-lasting increases in sharp wave-associated synaptic currents, exhibits enhanced excitatory synaptic strength in pyramidal cells that is induced postsynaptically and depends on metabotropic glutamate receptor-5 activation. In sharp contrast, alteration of inhibitory synaptic strength is independent of postsynaptic activation and less pronounced. Further, we found a cell type-specific, directionally biased synaptic plasticity of two major types of GABAergic cells, parvalbumin- and cholecystokinin-expressing interneurons. Thus, we propose that gamma frequency oscillations represent a network state that introduces long-lasting synaptic plasticity in a cell-specific manner. DOI: http://dx.doi.org/10.7554/eLife.14912.001 eLife Sciences Publications, Ltd 2016-05-24 /pmc/articles/PMC4929000/ /pubmed/27218453 http://dx.doi.org/10.7554/eLife.14912 Text en © 2016, Zarnadze et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Zarnadze, Shota
Bäuerle, Peter
Santos-Torres, Julio
Böhm, Claudia
Schmitz, Dietmar
Geiger, Jörg RP
Dugladze, Tamar
Gloveli, Tengis
Cell-specific synaptic plasticity induced by network oscillations
title Cell-specific synaptic plasticity induced by network oscillations
title_full Cell-specific synaptic plasticity induced by network oscillations
title_fullStr Cell-specific synaptic plasticity induced by network oscillations
title_full_unstemmed Cell-specific synaptic plasticity induced by network oscillations
title_short Cell-specific synaptic plasticity induced by network oscillations
title_sort cell-specific synaptic plasticity induced by network oscillations
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929000/
https://www.ncbi.nlm.nih.gov/pubmed/27218453
http://dx.doi.org/10.7554/eLife.14912
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