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Long-range population dynamics of anatomically defined neocortical networks

The coordination of activity across neocortical areas is essential for mammalian brain function. Understanding this process requires simultaneous functional measurements across the cortex. In order to dissociate direct cortico-cortical interactions from other sources of neuronal correlations, it is...

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Autores principales: Chen, Jerry L, Voigt, Fabian F, Javadzadeh, Mitra, Krueppel, Roland, Helmchen, Fritjof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929001/
https://www.ncbi.nlm.nih.gov/pubmed/27218452
http://dx.doi.org/10.7554/eLife.14679
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author Chen, Jerry L
Voigt, Fabian F
Javadzadeh, Mitra
Krueppel, Roland
Helmchen, Fritjof
author_facet Chen, Jerry L
Voigt, Fabian F
Javadzadeh, Mitra
Krueppel, Roland
Helmchen, Fritjof
author_sort Chen, Jerry L
collection PubMed
description The coordination of activity across neocortical areas is essential for mammalian brain function. Understanding this process requires simultaneous functional measurements across the cortex. In order to dissociate direct cortico-cortical interactions from other sources of neuronal correlations, it is furthermore desirable to target cross-areal recordings to neuronal subpopulations that anatomically project between areas. Here, we combined anatomical tracers with a novel multi-area two-photon microscope to perform simultaneous calcium imaging across mouse primary (S1) and secondary (S2) somatosensory whisker cortex during texture discrimination behavior, specifically identifying feedforward and feedback neurons. We find that coordination of S1-S2 activity increases during motor behaviors such as goal-directed whisking and licking. This effect was not specific to identified feedforward and feedback neurons. However, these mutually projecting neurons especially participated in inter-areal coordination when motor behavior was paired with whisker-texture touches, suggesting that direct S1-S2 interactions are sensory-dependent. Our results demonstrate specific functional coordination of anatomically-identified projection neurons across sensory cortices. DOI: http://dx.doi.org/10.7554/eLife.14679.001
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spelling pubmed-49290012016-07-05 Long-range population dynamics of anatomically defined neocortical networks Chen, Jerry L Voigt, Fabian F Javadzadeh, Mitra Krueppel, Roland Helmchen, Fritjof eLife Neuroscience The coordination of activity across neocortical areas is essential for mammalian brain function. Understanding this process requires simultaneous functional measurements across the cortex. In order to dissociate direct cortico-cortical interactions from other sources of neuronal correlations, it is furthermore desirable to target cross-areal recordings to neuronal subpopulations that anatomically project between areas. Here, we combined anatomical tracers with a novel multi-area two-photon microscope to perform simultaneous calcium imaging across mouse primary (S1) and secondary (S2) somatosensory whisker cortex during texture discrimination behavior, specifically identifying feedforward and feedback neurons. We find that coordination of S1-S2 activity increases during motor behaviors such as goal-directed whisking and licking. This effect was not specific to identified feedforward and feedback neurons. However, these mutually projecting neurons especially participated in inter-areal coordination when motor behavior was paired with whisker-texture touches, suggesting that direct S1-S2 interactions are sensory-dependent. Our results demonstrate specific functional coordination of anatomically-identified projection neurons across sensory cortices. DOI: http://dx.doi.org/10.7554/eLife.14679.001 eLife Sciences Publications, Ltd 2016-05-24 /pmc/articles/PMC4929001/ /pubmed/27218452 http://dx.doi.org/10.7554/eLife.14679 Text en © 2016, Chen et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Chen, Jerry L
Voigt, Fabian F
Javadzadeh, Mitra
Krueppel, Roland
Helmchen, Fritjof
Long-range population dynamics of anatomically defined neocortical networks
title Long-range population dynamics of anatomically defined neocortical networks
title_full Long-range population dynamics of anatomically defined neocortical networks
title_fullStr Long-range population dynamics of anatomically defined neocortical networks
title_full_unstemmed Long-range population dynamics of anatomically defined neocortical networks
title_short Long-range population dynamics of anatomically defined neocortical networks
title_sort long-range population dynamics of anatomically defined neocortical networks
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929001/
https://www.ncbi.nlm.nih.gov/pubmed/27218452
http://dx.doi.org/10.7554/eLife.14679
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