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A randomized phase I trial of nanoparticle albumin-bound paclitaxel with or without mifepristone for advanced breast cancer

PURPOSE: Glucocorticoid receptor (GR) overexpression is associated with poor prognosis ER-negative breast cancer. GR antagonism with mifepristone increases chemotherapy-induced breast cancer cell death, therefore we conducted a phase I clinical trial of mifepristone and nab-paclitaxel in advanced br...

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Detalles Bibliográficos
Autores principales:	Nanda, Rita, Stringer-Reasor, Erica M., Saha, Poornima, Kocherginsky, Masha, Gibson, Jean, Libao, Bernadette, Hoffman, Philip C., Obeid, Elias, Merkel, Douglas E., Khramtsova, Galina, Skor, Maxwell, Krausz, Thomas, Cohen, Ronald N., Ratain, Mark J., Fleming, Gini F., Conzen, Suzanne D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929099/ https://www.ncbi.nlm.nih.gov/pubmed/27386391 http://dx.doi.org/10.1186/s40064-016-2457-1

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