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Multidimensional endotyping in patients with severe asthma reveals inflammatory heterogeneity in matrix metalloproteinases and chitinase 3–like protein 1

BACKGROUND: Disease heterogeneity in patients with severe asthma and its relationship to inflammatory mechanisms remain poorly understood. OBJECTIVE: We aimed to identify and replicate clinicopathologic endotypes based on analysis of blood and sputum parameters in asthmatic patients. METHODS: One hu...

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Detalles Bibliográficos
Autores principales:	Hinks, Timothy S.C., Brown, Tom, Lau, Laurie C.K., Rupani, Hitasha, Barber, Clair, Elliott, Scott, Ward, Jon A., Ono, Junya, Ohta, Shoichiro, Izuhara, Kenji, Djukanović, Ratko, Kurukulaaratchy, Ramesh J., Chauhan, Anoop, Howarth, Peter H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Mosby 2016
Materias:	Asthma and Lower Airway Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929135/ https://www.ncbi.nlm.nih.gov/pubmed/26851968 http://dx.doi.org/10.1016/j.jaci.2015.11.020

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