Cargando…
Influence of cigarette smoking and inflammatory gene polymorphisms on glycated hemoglobin in the Japanese general population
OBJECTIVE: Inflammation is closely involved in the development of type 2 diabetes, and cigarette smoking acts as potent inducer of inflammation. We therefore investigated interactions between inflammation-related gene polymorphisms and cigarette smoking on glycated hemoglobin (HbA(1c)) in the Japane...
Autores principales: | , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929182/ https://www.ncbi.nlm.nih.gov/pubmed/27419029 http://dx.doi.org/10.1016/j.pmedr.2016.03.010 |
_version_ | 1782440569983729664 |
---|---|
author | Nishida, Yuichiro Hara, Megumi Sakamoto, Tatsuhiko Shinchi, Koichi Kawai, Sayo Naito, Mariko Hamajima, Nobuyuki Kadota, Aya Suzuki, Sadao Ibusuki, Rie Hirata, Akie Yamaguchi, Miwa Kuriyama, Nagato Oze, Isao Mikami, Haruo Kubo, Michiaki Tanaka, Hideo |
author_facet | Nishida, Yuichiro Hara, Megumi Sakamoto, Tatsuhiko Shinchi, Koichi Kawai, Sayo Naito, Mariko Hamajima, Nobuyuki Kadota, Aya Suzuki, Sadao Ibusuki, Rie Hirata, Akie Yamaguchi, Miwa Kuriyama, Nagato Oze, Isao Mikami, Haruo Kubo, Michiaki Tanaka, Hideo |
author_sort | Nishida, Yuichiro |
collection | PubMed |
description | OBJECTIVE: Inflammation is closely involved in the development of type 2 diabetes, and cigarette smoking acts as potent inducer of inflammation. We therefore investigated interactions between inflammation-related gene polymorphisms and cigarette smoking on glycated hemoglobin (HbA(1c)) in the Japanese general population. METHOD: We conducted a cross-sectional study using data collected from 2619 Japanese (1274 males and 1345 females) 40–69 years of age who participated in baseline survey of the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study (2005–2008). Eight polymorphisms in seven genes (interleukin [IL]-1β, IL-2, IL-4, IL-8, IL-10, IL-13 and tumor necrosis factor-α) were determined using the Invader assay. The interactions of smoking and gene polymorphisms on HbA(1c) levels were analyzed using multiple linear and logistic regression models and analysis of covariance with adjustment for potential confounders. RESULTS: Among the eight polymorphisms, only one significant interaction was detected for IL-1β T-31C (P < 0.0001). Among the subjects carrying TT genotype, current heavy smokers (≥ 20 cigarettes/day) had higher HbA(1c) (5.83 [95% confidence interval 5.67–5.99] %) versus all other smoking status groups (never 5.49 [5.41–5.56] %, former 5.54 [5.43–5.65] %, current moderate [< 20 cigarettes/day] 5.50 [5.30–5.69] %), whereas such differences were not observed in the subjects with C allele. The logistic regression analyses regarding high-normal HbA(1c) levels showed a similar pattern of results. CONCLUSION: Smoking status did not interact with any other inflammation-related polymorphisms except for IL-1β T-31C. Heavy smokers harboring the TT genotype of IL-1β T-31C polymorphism show a greater adverse effect of smoking on HbA(1c) levels among Japanese middle-aged subjects. |
format | Online Article Text |
id | pubmed-4929182 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-49291822016-07-14 Influence of cigarette smoking and inflammatory gene polymorphisms on glycated hemoglobin in the Japanese general population Nishida, Yuichiro Hara, Megumi Sakamoto, Tatsuhiko Shinchi, Koichi Kawai, Sayo Naito, Mariko Hamajima, Nobuyuki Kadota, Aya Suzuki, Sadao Ibusuki, Rie Hirata, Akie Yamaguchi, Miwa Kuriyama, Nagato Oze, Isao Mikami, Haruo Kubo, Michiaki Tanaka, Hideo Prev Med Rep Research paper OBJECTIVE: Inflammation is closely involved in the development of type 2 diabetes, and cigarette smoking acts as potent inducer of inflammation. We therefore investigated interactions between inflammation-related gene polymorphisms and cigarette smoking on glycated hemoglobin (HbA(1c)) in the Japanese general population. METHOD: We conducted a cross-sectional study using data collected from 2619 Japanese (1274 males and 1345 females) 40–69 years of age who participated in baseline survey of the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study (2005–2008). Eight polymorphisms in seven genes (interleukin [IL]-1β, IL-2, IL-4, IL-8, IL-10, IL-13 and tumor necrosis factor-α) were determined using the Invader assay. The interactions of smoking and gene polymorphisms on HbA(1c) levels were analyzed using multiple linear and logistic regression models and analysis of covariance with adjustment for potential confounders. RESULTS: Among the eight polymorphisms, only one significant interaction was detected for IL-1β T-31C (P < 0.0001). Among the subjects carrying TT genotype, current heavy smokers (≥ 20 cigarettes/day) had higher HbA(1c) (5.83 [95% confidence interval 5.67–5.99] %) versus all other smoking status groups (never 5.49 [5.41–5.56] %, former 5.54 [5.43–5.65] %, current moderate [< 20 cigarettes/day] 5.50 [5.30–5.69] %), whereas such differences were not observed in the subjects with C allele. The logistic regression analyses regarding high-normal HbA(1c) levels showed a similar pattern of results. CONCLUSION: Smoking status did not interact with any other inflammation-related polymorphisms except for IL-1β T-31C. Heavy smokers harboring the TT genotype of IL-1β T-31C polymorphism show a greater adverse effect of smoking on HbA(1c) levels among Japanese middle-aged subjects. Elsevier 2016-03-24 /pmc/articles/PMC4929182/ /pubmed/27419029 http://dx.doi.org/10.1016/j.pmedr.2016.03.010 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research paper Nishida, Yuichiro Hara, Megumi Sakamoto, Tatsuhiko Shinchi, Koichi Kawai, Sayo Naito, Mariko Hamajima, Nobuyuki Kadota, Aya Suzuki, Sadao Ibusuki, Rie Hirata, Akie Yamaguchi, Miwa Kuriyama, Nagato Oze, Isao Mikami, Haruo Kubo, Michiaki Tanaka, Hideo Influence of cigarette smoking and inflammatory gene polymorphisms on glycated hemoglobin in the Japanese general population |
title | Influence of cigarette smoking and inflammatory gene polymorphisms on glycated hemoglobin in the Japanese general population |
title_full | Influence of cigarette smoking and inflammatory gene polymorphisms on glycated hemoglobin in the Japanese general population |
title_fullStr | Influence of cigarette smoking and inflammatory gene polymorphisms on glycated hemoglobin in the Japanese general population |
title_full_unstemmed | Influence of cigarette smoking and inflammatory gene polymorphisms on glycated hemoglobin in the Japanese general population |
title_short | Influence of cigarette smoking and inflammatory gene polymorphisms on glycated hemoglobin in the Japanese general population |
title_sort | influence of cigarette smoking and inflammatory gene polymorphisms on glycated hemoglobin in the japanese general population |
topic | Research paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929182/ https://www.ncbi.nlm.nih.gov/pubmed/27419029 http://dx.doi.org/10.1016/j.pmedr.2016.03.010 |
work_keys_str_mv | AT nishidayuichiro influenceofcigarettesmokingandinflammatorygenepolymorphismsonglycatedhemoglobininthejapanesegeneralpopulation AT haramegumi influenceofcigarettesmokingandinflammatorygenepolymorphismsonglycatedhemoglobininthejapanesegeneralpopulation AT sakamototatsuhiko influenceofcigarettesmokingandinflammatorygenepolymorphismsonglycatedhemoglobininthejapanesegeneralpopulation AT shinchikoichi influenceofcigarettesmokingandinflammatorygenepolymorphismsonglycatedhemoglobininthejapanesegeneralpopulation AT kawaisayo influenceofcigarettesmokingandinflammatorygenepolymorphismsonglycatedhemoglobininthejapanesegeneralpopulation AT naitomariko influenceofcigarettesmokingandinflammatorygenepolymorphismsonglycatedhemoglobininthejapanesegeneralpopulation AT hamajimanobuyuki influenceofcigarettesmokingandinflammatorygenepolymorphismsonglycatedhemoglobininthejapanesegeneralpopulation AT kadotaaya influenceofcigarettesmokingandinflammatorygenepolymorphismsonglycatedhemoglobininthejapanesegeneralpopulation AT suzukisadao influenceofcigarettesmokingandinflammatorygenepolymorphismsonglycatedhemoglobininthejapanesegeneralpopulation AT ibusukirie influenceofcigarettesmokingandinflammatorygenepolymorphismsonglycatedhemoglobininthejapanesegeneralpopulation AT hirataakie influenceofcigarettesmokingandinflammatorygenepolymorphismsonglycatedhemoglobininthejapanesegeneralpopulation AT yamaguchimiwa influenceofcigarettesmokingandinflammatorygenepolymorphismsonglycatedhemoglobininthejapanesegeneralpopulation AT kuriyamanagato influenceofcigarettesmokingandinflammatorygenepolymorphismsonglycatedhemoglobininthejapanesegeneralpopulation AT ozeisao influenceofcigarettesmokingandinflammatorygenepolymorphismsonglycatedhemoglobininthejapanesegeneralpopulation AT mikamiharuo influenceofcigarettesmokingandinflammatorygenepolymorphismsonglycatedhemoglobininthejapanesegeneralpopulation AT kubomichiaki influenceofcigarettesmokingandinflammatorygenepolymorphismsonglycatedhemoglobininthejapanesegeneralpopulation AT tanakahideo influenceofcigarettesmokingandinflammatorygenepolymorphismsonglycatedhemoglobininthejapanesegeneralpopulation AT influenceofcigarettesmokingandinflammatorygenepolymorphismsonglycatedhemoglobininthejapanesegeneralpopulation |