Cargando…

Angiogenesis in Ischemic Stroke and Angiogenic Effects of Chinese Herbal Medicine

Stroke is one of the major causes of death and adult disability worldwide. The underlying pathophysiology of stroke is highly complicated, consisting of impairments of multiple signalling pathways, and numerous pathological processes such as acidosis, glutamate excitotoxicity, calcium overload, cere...

Descripción completa

Detalles Bibliográficos
Autores principales: Seto, Sai-Wang, Chang, Dennis, Jenkins, Anita, Bensoussan, Alan, Kiat, Hosen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929411/
https://www.ncbi.nlm.nih.gov/pubmed/27275837
http://dx.doi.org/10.3390/jcm5060056
_version_ 1782440602129924096
author Seto, Sai-Wang
Chang, Dennis
Jenkins, Anita
Bensoussan, Alan
Kiat, Hosen
author_facet Seto, Sai-Wang
Chang, Dennis
Jenkins, Anita
Bensoussan, Alan
Kiat, Hosen
author_sort Seto, Sai-Wang
collection PubMed
description Stroke is one of the major causes of death and adult disability worldwide. The underlying pathophysiology of stroke is highly complicated, consisting of impairments of multiple signalling pathways, and numerous pathological processes such as acidosis, glutamate excitotoxicity, calcium overload, cerebral inflammation and reactive oxygen species (ROS) generation. The current treatment for ischemic stroke is limited to thromolytics such as recombinant tissue plasminogen activator (tPA). tPA has a very narrow therapeutic window, making it suitable to only a minority of stroke patients. Hence, there is great urgency to develop new therapies that can protect brain tissue from ischemic damage. Recent studies have shown that new vessel formation after stroke not only replenishes blood flow to the ischemic area of the brain, but also promotes neurogenesis and improves neurological functions in both animal models and patients. Therefore, drugs that can promote angiogenesis after ischemic stroke can provide therapeutic benefits in stroke management. In this regard, Chinese herbal medicine (CHM) has a long history in treating stroke and the associated diseases. A number of studies have demonstrated the pro-angiogenic effects of various Chinese herbs and herbal formulations in both in vitro and in vivo settings. In this article, we present a comprehensive review of the current knowledge on angiogenesis in the context of ischemic stroke and discuss the potential use of CHM in stroke management through modulation of angiogenesis.
format Online
Article
Text
id pubmed-4929411
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-49294112016-07-07 Angiogenesis in Ischemic Stroke and Angiogenic Effects of Chinese Herbal Medicine Seto, Sai-Wang Chang, Dennis Jenkins, Anita Bensoussan, Alan Kiat, Hosen J Clin Med Review Stroke is one of the major causes of death and adult disability worldwide. The underlying pathophysiology of stroke is highly complicated, consisting of impairments of multiple signalling pathways, and numerous pathological processes such as acidosis, glutamate excitotoxicity, calcium overload, cerebral inflammation and reactive oxygen species (ROS) generation. The current treatment for ischemic stroke is limited to thromolytics such as recombinant tissue plasminogen activator (tPA). tPA has a very narrow therapeutic window, making it suitable to only a minority of stroke patients. Hence, there is great urgency to develop new therapies that can protect brain tissue from ischemic damage. Recent studies have shown that new vessel formation after stroke not only replenishes blood flow to the ischemic area of the brain, but also promotes neurogenesis and improves neurological functions in both animal models and patients. Therefore, drugs that can promote angiogenesis after ischemic stroke can provide therapeutic benefits in stroke management. In this regard, Chinese herbal medicine (CHM) has a long history in treating stroke and the associated diseases. A number of studies have demonstrated the pro-angiogenic effects of various Chinese herbs and herbal formulations in both in vitro and in vivo settings. In this article, we present a comprehensive review of the current knowledge on angiogenesis in the context of ischemic stroke and discuss the potential use of CHM in stroke management through modulation of angiogenesis. MDPI 2016-06-06 /pmc/articles/PMC4929411/ /pubmed/27275837 http://dx.doi.org/10.3390/jcm5060056 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Seto, Sai-Wang
Chang, Dennis
Jenkins, Anita
Bensoussan, Alan
Kiat, Hosen
Angiogenesis in Ischemic Stroke and Angiogenic Effects of Chinese Herbal Medicine
title Angiogenesis in Ischemic Stroke and Angiogenic Effects of Chinese Herbal Medicine
title_full Angiogenesis in Ischemic Stroke and Angiogenic Effects of Chinese Herbal Medicine
title_fullStr Angiogenesis in Ischemic Stroke and Angiogenic Effects of Chinese Herbal Medicine
title_full_unstemmed Angiogenesis in Ischemic Stroke and Angiogenic Effects of Chinese Herbal Medicine
title_short Angiogenesis in Ischemic Stroke and Angiogenic Effects of Chinese Herbal Medicine
title_sort angiogenesis in ischemic stroke and angiogenic effects of chinese herbal medicine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929411/
https://www.ncbi.nlm.nih.gov/pubmed/27275837
http://dx.doi.org/10.3390/jcm5060056
work_keys_str_mv AT setosaiwang angiogenesisinischemicstrokeandangiogeniceffectsofchineseherbalmedicine
AT changdennis angiogenesisinischemicstrokeandangiogeniceffectsofchineseherbalmedicine
AT jenkinsanita angiogenesisinischemicstrokeandangiogeniceffectsofchineseherbalmedicine
AT bensoussanalan angiogenesisinischemicstrokeandangiogeniceffectsofchineseherbalmedicine
AT kiathosen angiogenesisinischemicstrokeandangiogeniceffectsofchineseherbalmedicine