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Molecular Imaging of Angiogenesis and Vascular Remodeling in Cardiovascular Pathology

Angiogenesis and vascular remodeling are involved in a wide array of cardiovascular diseases, from myocardial ischemia and peripheral arterial disease, to atherosclerosis and aortic aneurysm. Molecular imaging techniques to detect and quantify key molecular and cellular players in angiogenesis and v...

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Detalles Bibliográficos
Autores principales: Golestani, Reza, Jung, Jae-Joon, Sadeghi, Mehran M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929412/
https://www.ncbi.nlm.nih.gov/pubmed/27275836
http://dx.doi.org/10.3390/jcm5060057
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author Golestani, Reza
Jung, Jae-Joon
Sadeghi, Mehran M.
author_facet Golestani, Reza
Jung, Jae-Joon
Sadeghi, Mehran M.
author_sort Golestani, Reza
collection PubMed
description Angiogenesis and vascular remodeling are involved in a wide array of cardiovascular diseases, from myocardial ischemia and peripheral arterial disease, to atherosclerosis and aortic aneurysm. Molecular imaging techniques to detect and quantify key molecular and cellular players in angiogenesis and vascular remodeling (e.g., vascular endothelial growth factor and its receptors, αvβ3 integrin, and matrix metalloproteinases) can advance vascular biology research and serve as clinical tools for early diagnosis, risk stratification, and selection of patients who would benefit most from therapeutic interventions. To target these key mediators, a number of molecular imaging techniques have been developed and evaluated in animal models of angiogenesis and vascular remodeling. This review of the state of the art molecular imaging of angiogenesis and vascular (and valvular) remodeling, will focus mostly on nuclear imaging techniques (positron emission tomography and single photon emission tomography) that offer high potential for clinical translation.
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spelling pubmed-49294122016-07-07 Molecular Imaging of Angiogenesis and Vascular Remodeling in Cardiovascular Pathology Golestani, Reza Jung, Jae-Joon Sadeghi, Mehran M. J Clin Med Review Angiogenesis and vascular remodeling are involved in a wide array of cardiovascular diseases, from myocardial ischemia and peripheral arterial disease, to atherosclerosis and aortic aneurysm. Molecular imaging techniques to detect and quantify key molecular and cellular players in angiogenesis and vascular remodeling (e.g., vascular endothelial growth factor and its receptors, αvβ3 integrin, and matrix metalloproteinases) can advance vascular biology research and serve as clinical tools for early diagnosis, risk stratification, and selection of patients who would benefit most from therapeutic interventions. To target these key mediators, a number of molecular imaging techniques have been developed and evaluated in animal models of angiogenesis and vascular remodeling. This review of the state of the art molecular imaging of angiogenesis and vascular (and valvular) remodeling, will focus mostly on nuclear imaging techniques (positron emission tomography and single photon emission tomography) that offer high potential for clinical translation. MDPI 2016-06-06 /pmc/articles/PMC4929412/ /pubmed/27275836 http://dx.doi.org/10.3390/jcm5060057 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Golestani, Reza
Jung, Jae-Joon
Sadeghi, Mehran M.
Molecular Imaging of Angiogenesis and Vascular Remodeling in Cardiovascular Pathology
title Molecular Imaging of Angiogenesis and Vascular Remodeling in Cardiovascular Pathology
title_full Molecular Imaging of Angiogenesis and Vascular Remodeling in Cardiovascular Pathology
title_fullStr Molecular Imaging of Angiogenesis and Vascular Remodeling in Cardiovascular Pathology
title_full_unstemmed Molecular Imaging of Angiogenesis and Vascular Remodeling in Cardiovascular Pathology
title_short Molecular Imaging of Angiogenesis and Vascular Remodeling in Cardiovascular Pathology
title_sort molecular imaging of angiogenesis and vascular remodeling in cardiovascular pathology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929412/
https://www.ncbi.nlm.nih.gov/pubmed/27275836
http://dx.doi.org/10.3390/jcm5060057
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