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Antibiotics and RNase P

RNase P is an essential endonuclease in tRNA biogenesis, which generates the mature 5′-termini of tRNAs. Most forms of RNase P are ribonucleoproteins, i.e., they consist of an essential RNA and protein subunits. The catalytic function of ribonucleoprotein RNase P enzymes resides entirely in the RNA...

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Detalles Bibliográficos
Autor principal: Drainas, Denis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929430/
https://www.ncbi.nlm.nih.gov/pubmed/27164152
http://dx.doi.org/10.3390/antibiotics5020015
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author Drainas, Denis
author_facet Drainas, Denis
author_sort Drainas, Denis
collection PubMed
description RNase P is an essential endonuclease in tRNA biogenesis, which generates the mature 5′-termini of tRNAs. Most forms of RNase P are ribonucleoproteins, i.e., they consist of an essential RNA and protein subunits. The catalytic function of ribonucleoprotein RNase P enzymes resides entirely in the RNA subunit. Its high structural and functional diversity among representatives of a vast variety of phylogenetic domains indicates that RNase P could serve as a molecular target and a useful screening system for the development of new drugs in the battle against bacterial drug resistance.
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spelling pubmed-49294302016-07-07 Antibiotics and RNase P Drainas, Denis Antibiotics (Basel) Review RNase P is an essential endonuclease in tRNA biogenesis, which generates the mature 5′-termini of tRNAs. Most forms of RNase P are ribonucleoproteins, i.e., they consist of an essential RNA and protein subunits. The catalytic function of ribonucleoprotein RNase P enzymes resides entirely in the RNA subunit. Its high structural and functional diversity among representatives of a vast variety of phylogenetic domains indicates that RNase P could serve as a molecular target and a useful screening system for the development of new drugs in the battle against bacterial drug resistance. MDPI 2016-05-06 /pmc/articles/PMC4929430/ /pubmed/27164152 http://dx.doi.org/10.3390/antibiotics5020015 Text en © 2016 by the author; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Drainas, Denis
Antibiotics and RNase P
title Antibiotics and RNase P
title_full Antibiotics and RNase P
title_fullStr Antibiotics and RNase P
title_full_unstemmed Antibiotics and RNase P
title_short Antibiotics and RNase P
title_sort antibiotics and rnase p
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929430/
https://www.ncbi.nlm.nih.gov/pubmed/27164152
http://dx.doi.org/10.3390/antibiotics5020015
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