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Antibiotics and RNase P
RNase P is an essential endonuclease in tRNA biogenesis, which generates the mature 5′-termini of tRNAs. Most forms of RNase P are ribonucleoproteins, i.e., they consist of an essential RNA and protein subunits. The catalytic function of ribonucleoprotein RNase P enzymes resides entirely in the RNA...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929430/ https://www.ncbi.nlm.nih.gov/pubmed/27164152 http://dx.doi.org/10.3390/antibiotics5020015 |
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author | Drainas, Denis |
author_facet | Drainas, Denis |
author_sort | Drainas, Denis |
collection | PubMed |
description | RNase P is an essential endonuclease in tRNA biogenesis, which generates the mature 5′-termini of tRNAs. Most forms of RNase P are ribonucleoproteins, i.e., they consist of an essential RNA and protein subunits. The catalytic function of ribonucleoprotein RNase P enzymes resides entirely in the RNA subunit. Its high structural and functional diversity among representatives of a vast variety of phylogenetic domains indicates that RNase P could serve as a molecular target and a useful screening system for the development of new drugs in the battle against bacterial drug resistance. |
format | Online Article Text |
id | pubmed-4929430 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-49294302016-07-07 Antibiotics and RNase P Drainas, Denis Antibiotics (Basel) Review RNase P is an essential endonuclease in tRNA biogenesis, which generates the mature 5′-termini of tRNAs. Most forms of RNase P are ribonucleoproteins, i.e., they consist of an essential RNA and protein subunits. The catalytic function of ribonucleoprotein RNase P enzymes resides entirely in the RNA subunit. Its high structural and functional diversity among representatives of a vast variety of phylogenetic domains indicates that RNase P could serve as a molecular target and a useful screening system for the development of new drugs in the battle against bacterial drug resistance. MDPI 2016-05-06 /pmc/articles/PMC4929430/ /pubmed/27164152 http://dx.doi.org/10.3390/antibiotics5020015 Text en © 2016 by the author; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Drainas, Denis Antibiotics and RNase P |
title | Antibiotics and RNase P |
title_full | Antibiotics and RNase P |
title_fullStr | Antibiotics and RNase P |
title_full_unstemmed | Antibiotics and RNase P |
title_short | Antibiotics and RNase P |
title_sort | antibiotics and rnase p |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929430/ https://www.ncbi.nlm.nih.gov/pubmed/27164152 http://dx.doi.org/10.3390/antibiotics5020015 |
work_keys_str_mv | AT drainasdenis antibioticsandrnasep |