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Small Molecule Docking Supports Broad and Narrow Spectrum Potential for the Inhibition of the Novel Antibiotic Target Bacterial Pth1

Peptidyl-tRNA hydrolases (Pths) play ancillary yet essential roles in protein biosynthesis by recycling peptidyl-tRNA. In E. coli, inhibition of bacterial Pth1 leads to accumulation of peptidyl-tRNA, depletion of aminoacyl-tRNA, and cell death. Eukaryotes have multiple Pths and Pth1 knock out was sh...

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Detalles Bibliográficos
Autores principales:	Ferguson, Paul P., Holloway, W. Blake, Setzer, William N., McFeeters, Hana, McFeeters, Robert L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929431/ https://www.ncbi.nlm.nih.gov/pubmed/27171117 http://dx.doi.org/10.3390/antibiotics5020016

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