Abrogating ClC-3 Inhibits LPS-induced Inflammation via Blocking the TLR4/NF-κB Pathway

This study investigated the function of a chloride channel blocker, DIDS. Both in vitro and in vivo studies found that DIDS significantly inhibits lipopolysaccharide (LPS)-induced release of proin flammatory cytokines. Here, we show that DIDS inhibits LPS-induced inflammation, as shown by downregula...

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Detalles Bibliográficos
Autores principales: Xiang, Nan-lin, Liu, Jun, Liao, Yun-jian, Huang, You-wei, Wu, Zheng, Bai, Zhi-quan, Lin, Xi, Zhang, Jian-hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929440/
https://www.ncbi.nlm.nih.gov/pubmed/27363391
http://dx.doi.org/10.1038/srep27583

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929440/
https://www.ncbi.nlm.nih.gov/pubmed/27363391
http://dx.doi.org/10.1038/srep27583

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