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Catalysts of DNA Strand Cleavage at Apurinic/Apyrimidinic Sites

Apurinic/apyrimidinic (AP) sites are constantly formed in cellular DNA due to instability of the glycosidic bond, particularly at purines and various oxidized, alkylated, or otherwise damaged nucleobases. AP sites are also generated by DNA glycosylases that initiate DNA base excision repair. These l...

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Detalles Bibliográficos
Autores principales:	Minko, Irina G., Jacobs, Aaron C., de Leon, Arnie R., Gruppi, Francesca, Donley, Nathan, Harris, Thomas M., Rizzo, Carmelo J., McCullough, Amanda K., Lloyd, R. Stephen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929455/ https://www.ncbi.nlm.nih.gov/pubmed/27363485 http://dx.doi.org/10.1038/srep28894

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