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The Pseudouridine Synthases Proceed through a Glycal Intermediate
[Image: see text] The pseudouridine synthases isomerize (U) in RNA to pseudouridine (Ψ), and the mechanism that they follow has long been a question of interest. The recent elucidation of a product of the mechanistic probe 5-fluorouridine that had been epimerized to the arabino isomer suggested that...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929527/ https://www.ncbi.nlm.nih.gov/pubmed/27292228 http://dx.doi.org/10.1021/jacs.6b04491 |