Interleukin-1β has trophic effects in microglia and its release is mediated by P2X7R pore

BACKGROUND: Enhanced expression of the purinergic P2X7 receptor (P2X7R) occurs in several neuroinflammatory conditions where increased microglial activation is a co-existing feature. P2X7 receptors can function either as a cation channel or, upon continued stimulation, a large pore. P2X7R-over-expre...

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Detalles Bibliográficos
Autores principales: Monif, Mastura, Reid, Christopher A., Powell, Kim L., Drummond, Katherine J., O’Brien, Terrence J., Williams, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929731/
https://www.ncbi.nlm.nih.gov/pubmed/27364756
http://dx.doi.org/10.1186/s12974-016-0621-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929731/
https://www.ncbi.nlm.nih.gov/pubmed/27364756
http://dx.doi.org/10.1186/s12974-016-0621-8

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