Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence

We conducted a 1000 Genomes–imputed genome-wide association study (GWAS) meta-analysis for nicotine dependence, defined by the Fagerström Test for Nicotine Dependence in 17 074 ever smokers from five European-ancestry samples. We followed up novel variants in 7469 ever smokers from five independent...

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Detalles Bibliográficos
Autores principales: Hancock, D B, Reginsson, G W, Gaddis, N C, Chen, X, Saccone, N L, Lutz, S M, Qaiser, B, Sherva, R, Steinberg, S, Zink, F, Stacey, S N, Glasheen, C, Chen, J, Gu, F, Frederiksen, B N, Loukola, A, Gudbjartsson, D F, Brüske, I, Landi, M T, Bickeböller, H, Madden, P, Farrer, L, Kaprio, J, Kranzler, H R, Gelernter, J, Baker, T B, Kraft, P, Amos, C I, Caporaso, N E, Hokanson, J E, Bierut, L J, Thorgeirsson, T E, Johnson, E O, Stefansson, K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930126/
https://www.ncbi.nlm.nih.gov/pubmed/26440539
http://dx.doi.org/10.1038/tp.2015.149

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