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Human and Murine Hematopoietic Stem Cell Aging Is Associated with Functional Impairments and Intrinsic Megakaryocytic/Erythroid Bias

Aging within the human hematopoietic system associates with various deficiencies and disease states, including anemia, myeloid neoplasms and reduced adaptive immune responses. Similar phenotypes are observed in mice and have been linked to alterations arising at the hematopoietic stem cell (HSC) lev...

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Detalles Bibliográficos
Autores principales:	Rundberg Nilsson, Alexandra, Soneji, Shamit, Adolfsson, Sofia, Bryder, David, Pronk, Cornelis Jan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930192/ https://www.ncbi.nlm.nih.gov/pubmed/27368054 http://dx.doi.org/10.1371/journal.pone.0158369

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