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Serum Soluble (Pro)Renin Receptor Levels in Maintenance Hemodialysis Patients

The (pro)renin receptor [(P)RR] is cleaved by furin to generate soluble (P)RR [s(P)RR], which reflects the status of the tissue renin-angiotensin system. Hemodialysis patients have advanced atherosclerosis. The aim of this study was to investigate the relationships between serum s(P)RR levels and ba...

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Autores principales: Amari, Yoshifumi, Morimoto, Satoshi, Nakajima, Fumitaka, Ando, Takashi, Ichihara, Atsuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930198/
https://www.ncbi.nlm.nih.gov/pubmed/27367528
http://dx.doi.org/10.1371/journal.pone.0158068
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author Amari, Yoshifumi
Morimoto, Satoshi
Nakajima, Fumitaka
Ando, Takashi
Ichihara, Atsuhiro
author_facet Amari, Yoshifumi
Morimoto, Satoshi
Nakajima, Fumitaka
Ando, Takashi
Ichihara, Atsuhiro
author_sort Amari, Yoshifumi
collection PubMed
description The (pro)renin receptor [(P)RR] is cleaved by furin to generate soluble (P)RR [s(P)RR], which reflects the status of the tissue renin-angiotensin system. Hemodialysis patients have advanced atherosclerosis. The aim of this study was to investigate the relationships between serum s(P)RR levels and background factors, including indices of atherosclerosis, in hemodialysis patients. Serum s(P)RR levels were measured in hemodialysis patients and clearance of s(P)RR through the membrane of the dialyzer was examined. Furthermore, relationships between serum s(P)RR levels and background factors were assessed. Serum s(P)RR levels were significantly higher in hemodialysis patients (30.4 ± 6.1 ng/ml, n = 258) than those in subjects with normal renal function (21.4 ± 6.2 ng/ml, n = 39, P < 0.0001). Clearance of s(P)RR and creatinine were 56.9 ± 33.5 and 147.6 ± 9.50 ml/min, respectively. Serum s(P)RR levels were significantly higher in those with ankle-brachial index (ABI) of < 0.9, an indicator of severe atherosclerosis, than those with ABI of ≥ 0.9 (32.2 ± 5.9 and 30.1 ± 6.2 ng/ml, respectively, P < 0.05). An association between low ABI and high serum s(P)RR levels was observed even after correction for age, history of smoking, HbA1c, and LDL-C. Serum s(P)RR levels were significantly higher in hemodialysis patients when compared with subjects with normal renal function, although s(P)RR is dialyzed to some extent, but to a lesser extent than creatinine. High serum s(P)RR levels may be associated with atherosclerosis independent of other risk factors, suggesting that serum s(P)RR could be used as a marker for atherosclerotic conditions in hemodialysis patients.
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spelling pubmed-49301982016-07-18 Serum Soluble (Pro)Renin Receptor Levels in Maintenance Hemodialysis Patients Amari, Yoshifumi Morimoto, Satoshi Nakajima, Fumitaka Ando, Takashi Ichihara, Atsuhiro PLoS One Research Article The (pro)renin receptor [(P)RR] is cleaved by furin to generate soluble (P)RR [s(P)RR], which reflects the status of the tissue renin-angiotensin system. Hemodialysis patients have advanced atherosclerosis. The aim of this study was to investigate the relationships between serum s(P)RR levels and background factors, including indices of atherosclerosis, in hemodialysis patients. Serum s(P)RR levels were measured in hemodialysis patients and clearance of s(P)RR through the membrane of the dialyzer was examined. Furthermore, relationships between serum s(P)RR levels and background factors were assessed. Serum s(P)RR levels were significantly higher in hemodialysis patients (30.4 ± 6.1 ng/ml, n = 258) than those in subjects with normal renal function (21.4 ± 6.2 ng/ml, n = 39, P < 0.0001). Clearance of s(P)RR and creatinine were 56.9 ± 33.5 and 147.6 ± 9.50 ml/min, respectively. Serum s(P)RR levels were significantly higher in those with ankle-brachial index (ABI) of < 0.9, an indicator of severe atherosclerosis, than those with ABI of ≥ 0.9 (32.2 ± 5.9 and 30.1 ± 6.2 ng/ml, respectively, P < 0.05). An association between low ABI and high serum s(P)RR levels was observed even after correction for age, history of smoking, HbA1c, and LDL-C. Serum s(P)RR levels were significantly higher in hemodialysis patients when compared with subjects with normal renal function, although s(P)RR is dialyzed to some extent, but to a lesser extent than creatinine. High serum s(P)RR levels may be associated with atherosclerosis independent of other risk factors, suggesting that serum s(P)RR could be used as a marker for atherosclerotic conditions in hemodialysis patients. Public Library of Science 2016-07-01 /pmc/articles/PMC4930198/ /pubmed/27367528 http://dx.doi.org/10.1371/journal.pone.0158068 Text en © 2016 Amari et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Amari, Yoshifumi
Morimoto, Satoshi
Nakajima, Fumitaka
Ando, Takashi
Ichihara, Atsuhiro
Serum Soluble (Pro)Renin Receptor Levels in Maintenance Hemodialysis Patients
title Serum Soluble (Pro)Renin Receptor Levels in Maintenance Hemodialysis Patients
title_full Serum Soluble (Pro)Renin Receptor Levels in Maintenance Hemodialysis Patients
title_fullStr Serum Soluble (Pro)Renin Receptor Levels in Maintenance Hemodialysis Patients
title_full_unstemmed Serum Soluble (Pro)Renin Receptor Levels in Maintenance Hemodialysis Patients
title_short Serum Soluble (Pro)Renin Receptor Levels in Maintenance Hemodialysis Patients
title_sort serum soluble (pro)renin receptor levels in maintenance hemodialysis patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930198/
https://www.ncbi.nlm.nih.gov/pubmed/27367528
http://dx.doi.org/10.1371/journal.pone.0158068
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