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The clinical significance of γ-catenin in acute myeloid leukemia

Dysregulation of γ-catenin may function as an oncogenic factor in various malignancies. We investigated γ-catenin expression in acute myeloid leukemia (AML) and explored its role in the pathogenesis of AML. γ-Catenin was significantly overexpressed in AML patients compared to healthy donors. The γ-c...

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Autores principales: Xu, Jiadai, Wu, Wei, Shen, Wenyi, Liu, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930232/
https://www.ncbi.nlm.nih.gov/pubmed/27390526
http://dx.doi.org/10.2147/OTT.S105514
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author Xu, Jiadai
Wu, Wei
Shen, Wenyi
Liu, Peng
author_facet Xu, Jiadai
Wu, Wei
Shen, Wenyi
Liu, Peng
author_sort Xu, Jiadai
collection PubMed
description Dysregulation of γ-catenin may function as an oncogenic factor in various malignancies. We investigated γ-catenin expression in acute myeloid leukemia (AML) and explored its role in the pathogenesis of AML. γ-Catenin was significantly overexpressed in AML patients compared to healthy donors. The γ-catenin expression in AML patients with lower white blood cells (<30×10(9)/L) was significantly higher than those with higher white blood cells (≥30×10(9)/L). The expression levels of γ-catenin in AML patients with mutated CEBPα were significantly higher than those with unmutated CEBPα. AML patients with lower γ-catenin levels were more likely to achieve complete remission compared with patients who have higher γ-catenin levels. In K562 cells, γ-catenin knockdown suppressed cellular proliferation, while the cellular migration was greatly enhanced. Moreover, knocking down of γ-catenin enhanced the cytotoxicity of decitabine in K562 cells. Our investigation has indicated a potential role of γ-catenin in the pathogenesis of AML.
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spelling pubmed-49302322016-07-07 The clinical significance of γ-catenin in acute myeloid leukemia Xu, Jiadai Wu, Wei Shen, Wenyi Liu, Peng Onco Targets Ther Original Research Dysregulation of γ-catenin may function as an oncogenic factor in various malignancies. We investigated γ-catenin expression in acute myeloid leukemia (AML) and explored its role in the pathogenesis of AML. γ-Catenin was significantly overexpressed in AML patients compared to healthy donors. The γ-catenin expression in AML patients with lower white blood cells (<30×10(9)/L) was significantly higher than those with higher white blood cells (≥30×10(9)/L). The expression levels of γ-catenin in AML patients with mutated CEBPα were significantly higher than those with unmutated CEBPα. AML patients with lower γ-catenin levels were more likely to achieve complete remission compared with patients who have higher γ-catenin levels. In K562 cells, γ-catenin knockdown suppressed cellular proliferation, while the cellular migration was greatly enhanced. Moreover, knocking down of γ-catenin enhanced the cytotoxicity of decitabine in K562 cells. Our investigation has indicated a potential role of γ-catenin in the pathogenesis of AML. Dove Medical Press 2016-06-27 /pmc/articles/PMC4930232/ /pubmed/27390526 http://dx.doi.org/10.2147/OTT.S105514 Text en © 2016 Xu et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Xu, Jiadai
Wu, Wei
Shen, Wenyi
Liu, Peng
The clinical significance of γ-catenin in acute myeloid leukemia
title The clinical significance of γ-catenin in acute myeloid leukemia
title_full The clinical significance of γ-catenin in acute myeloid leukemia
title_fullStr The clinical significance of γ-catenin in acute myeloid leukemia
title_full_unstemmed The clinical significance of γ-catenin in acute myeloid leukemia
title_short The clinical significance of γ-catenin in acute myeloid leukemia
title_sort clinical significance of γ-catenin in acute myeloid leukemia
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930232/
https://www.ncbi.nlm.nih.gov/pubmed/27390526
http://dx.doi.org/10.2147/OTT.S105514
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