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The clinical significance of γ-catenin in acute myeloid leukemia
Dysregulation of γ-catenin may function as an oncogenic factor in various malignancies. We investigated γ-catenin expression in acute myeloid leukemia (AML) and explored its role in the pathogenesis of AML. γ-Catenin was significantly overexpressed in AML patients compared to healthy donors. The γ-c...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930232/ https://www.ncbi.nlm.nih.gov/pubmed/27390526 http://dx.doi.org/10.2147/OTT.S105514 |
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author | Xu, Jiadai Wu, Wei Shen, Wenyi Liu, Peng |
author_facet | Xu, Jiadai Wu, Wei Shen, Wenyi Liu, Peng |
author_sort | Xu, Jiadai |
collection | PubMed |
description | Dysregulation of γ-catenin may function as an oncogenic factor in various malignancies. We investigated γ-catenin expression in acute myeloid leukemia (AML) and explored its role in the pathogenesis of AML. γ-Catenin was significantly overexpressed in AML patients compared to healthy donors. The γ-catenin expression in AML patients with lower white blood cells (<30×10(9)/L) was significantly higher than those with higher white blood cells (≥30×10(9)/L). The expression levels of γ-catenin in AML patients with mutated CEBPα were significantly higher than those with unmutated CEBPα. AML patients with lower γ-catenin levels were more likely to achieve complete remission compared with patients who have higher γ-catenin levels. In K562 cells, γ-catenin knockdown suppressed cellular proliferation, while the cellular migration was greatly enhanced. Moreover, knocking down of γ-catenin enhanced the cytotoxicity of decitabine in K562 cells. Our investigation has indicated a potential role of γ-catenin in the pathogenesis of AML. |
format | Online Article Text |
id | pubmed-4930232 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-49302322016-07-07 The clinical significance of γ-catenin in acute myeloid leukemia Xu, Jiadai Wu, Wei Shen, Wenyi Liu, Peng Onco Targets Ther Original Research Dysregulation of γ-catenin may function as an oncogenic factor in various malignancies. We investigated γ-catenin expression in acute myeloid leukemia (AML) and explored its role in the pathogenesis of AML. γ-Catenin was significantly overexpressed in AML patients compared to healthy donors. The γ-catenin expression in AML patients with lower white blood cells (<30×10(9)/L) was significantly higher than those with higher white blood cells (≥30×10(9)/L). The expression levels of γ-catenin in AML patients with mutated CEBPα were significantly higher than those with unmutated CEBPα. AML patients with lower γ-catenin levels were more likely to achieve complete remission compared with patients who have higher γ-catenin levels. In K562 cells, γ-catenin knockdown suppressed cellular proliferation, while the cellular migration was greatly enhanced. Moreover, knocking down of γ-catenin enhanced the cytotoxicity of decitabine in K562 cells. Our investigation has indicated a potential role of γ-catenin in the pathogenesis of AML. Dove Medical Press 2016-06-27 /pmc/articles/PMC4930232/ /pubmed/27390526 http://dx.doi.org/10.2147/OTT.S105514 Text en © 2016 Xu et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Xu, Jiadai Wu, Wei Shen, Wenyi Liu, Peng The clinical significance of γ-catenin in acute myeloid leukemia |
title | The clinical significance of γ-catenin in acute myeloid leukemia |
title_full | The clinical significance of γ-catenin in acute myeloid leukemia |
title_fullStr | The clinical significance of γ-catenin in acute myeloid leukemia |
title_full_unstemmed | The clinical significance of γ-catenin in acute myeloid leukemia |
title_short | The clinical significance of γ-catenin in acute myeloid leukemia |
title_sort | clinical significance of γ-catenin in acute myeloid leukemia |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930232/ https://www.ncbi.nlm.nih.gov/pubmed/27390526 http://dx.doi.org/10.2147/OTT.S105514 |
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