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A “twisted” microfluidic mixer suitable for a wide range of flow rate applications

This paper proposes a new “twisted” 3D microfluidic mixer fabricated by a laser writing/microfabrication technique. Effective and efficient mixing using the twisted micromixers can be obtained by combining two general chaotic mixing mechanisms: splitting/recombining and chaotic advection. The lamina...

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Autores principales: Sivashankar, Shilpa, Agambayev, Sumeyra, Mashraei, Yousof, Li, Er Qiang, Thoroddsen, Sigurdur T., Salama, Khaled Nabil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AIP Publishing LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930447/
https://www.ncbi.nlm.nih.gov/pubmed/27453767
http://dx.doi.org/10.1063/1.4954812
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author Sivashankar, Shilpa
Agambayev, Sumeyra
Mashraei, Yousof
Li, Er Qiang
Thoroddsen, Sigurdur T.
Salama, Khaled Nabil
author_facet Sivashankar, Shilpa
Agambayev, Sumeyra
Mashraei, Yousof
Li, Er Qiang
Thoroddsen, Sigurdur T.
Salama, Khaled Nabil
author_sort Sivashankar, Shilpa
collection PubMed
description This paper proposes a new “twisted” 3D microfluidic mixer fabricated by a laser writing/microfabrication technique. Effective and efficient mixing using the twisted micromixers can be obtained by combining two general chaotic mixing mechanisms: splitting/recombining and chaotic advection. The lamination of mixer units provides the splitting and recombination mechanism when the quadrant of circles is arranged in a two-layered serial arrangement of mixing units. The overall 3D path of the microchannel introduces the advection. An experimental investigation using chemical solutions revealed that these novel 3D passive microfluidic mixers were stable and could be operated at a wide range of flow rates. This micromixer finds application in the manipulation of tiny volumes of liquids that are crucial in diagnostics. The mixing performance was evaluated by dye visualization, and using a pH test that determined the chemical reaction of the solutions. A comparison of the tornado-mixer with this twisted micromixer was made to evaluate the efficiency of mixing. The efficiency of mixing was calculated within the channel by acquiring intensities using ImageJ software. Results suggested that efficient mixing can be obtained when more than 3 units were consecutively placed. The geometry of the device, which has a length of 30 mm, enables the device to be integrated with micro total analysis systems and other lab-on-chip devices.
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spelling pubmed-49304472016-07-22 A “twisted” microfluidic mixer suitable for a wide range of flow rate applications Sivashankar, Shilpa Agambayev, Sumeyra Mashraei, Yousof Li, Er Qiang Thoroddsen, Sigurdur T. Salama, Khaled Nabil Biomicrofluidics Regular Articles This paper proposes a new “twisted” 3D microfluidic mixer fabricated by a laser writing/microfabrication technique. Effective and efficient mixing using the twisted micromixers can be obtained by combining two general chaotic mixing mechanisms: splitting/recombining and chaotic advection. The lamination of mixer units provides the splitting and recombination mechanism when the quadrant of circles is arranged in a two-layered serial arrangement of mixing units. The overall 3D path of the microchannel introduces the advection. An experimental investigation using chemical solutions revealed that these novel 3D passive microfluidic mixers were stable and could be operated at a wide range of flow rates. This micromixer finds application in the manipulation of tiny volumes of liquids that are crucial in diagnostics. The mixing performance was evaluated by dye visualization, and using a pH test that determined the chemical reaction of the solutions. A comparison of the tornado-mixer with this twisted micromixer was made to evaluate the efficiency of mixing. The efficiency of mixing was calculated within the channel by acquiring intensities using ImageJ software. Results suggested that efficient mixing can be obtained when more than 3 units were consecutively placed. The geometry of the device, which has a length of 30 mm, enables the device to be integrated with micro total analysis systems and other lab-on-chip devices. AIP Publishing LLC 2016-06-27 /pmc/articles/PMC4930447/ /pubmed/27453767 http://dx.doi.org/10.1063/1.4954812 Text en © 2016 Author(s). 1932-1058/2016/10(3)/034120/13 All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Regular Articles
Sivashankar, Shilpa
Agambayev, Sumeyra
Mashraei, Yousof
Li, Er Qiang
Thoroddsen, Sigurdur T.
Salama, Khaled Nabil
A “twisted” microfluidic mixer suitable for a wide range of flow rate applications
title A “twisted” microfluidic mixer suitable for a wide range of flow rate applications
title_full A “twisted” microfluidic mixer suitable for a wide range of flow rate applications
title_fullStr A “twisted” microfluidic mixer suitable for a wide range of flow rate applications
title_full_unstemmed A “twisted” microfluidic mixer suitable for a wide range of flow rate applications
title_short A “twisted” microfluidic mixer suitable for a wide range of flow rate applications
title_sort “twisted” microfluidic mixer suitable for a wide range of flow rate applications
topic Regular Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930447/
https://www.ncbi.nlm.nih.gov/pubmed/27453767
http://dx.doi.org/10.1063/1.4954812
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