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Lysosomal acid lipase regulates VLDL synthesis and insulin sensitivity in mice

AIMS/HYPOTHESIS: Lysosomal acid lipase (LAL) hydrolyses cholesteryl esters and triacylglycerols (TG) within lysosomes to mobilise NEFA and cholesterol. Since LAL-deficient (Lal(-/-)) mice suffer from progressive loss of adipose tissue and severe accumulation of lipids in hepatic lysosomes, we hypoth...

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Detalles Bibliográficos
Autores principales:	Radović, Branislav, Vujić, Nemanja, Leopold, Christina, Schlager, Stefanie, Goeritzer, Madeleine, Patankar, Jay V., Korbelius, Melanie, Kolb, Dagmar, Reindl, Julia, Wegscheider, Martin, Tomin, Tamara, Birner-Gruenberger, Ruth, Schittmayer, Matthias, Groschner, Lukas, Magnes, Christoph, Diwoky, Clemens, Frank, Saša, Steyrer, Ernst, Du, Hong, Graier, Wolfgang F., Madl, Tobias, Kratky, Dagmar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930475/ https://www.ncbi.nlm.nih.gov/pubmed/27153842 http://dx.doi.org/10.1007/s00125-016-3968-6

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