Dynamic Axonal Translation in Developing and Mature Visual Circuits

Local mRNA translation mediates the adaptive responses of axons to extrinsic signals, but direct evidence that it occurs in mammalian CNS axons in vivo is scant. We developed an axon-TRAP-RiboTag approach in mouse that allows deep-sequencing analysis of ribosome-bound mRNAs in the retinal ganglion c...

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Detalles Bibliográficos
Autores principales: Shigeoka, Toshiaki, Jung, Hosung, Jung, Jane, Turner-Bridger, Benita, Ohk, Jiyeon, Lin, Julie Qiaojin, Amieux, Paul S., Holt, Christine E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930487/
https://www.ncbi.nlm.nih.gov/pubmed/27321671
http://dx.doi.org/10.1016/j.cell.2016.05.029

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