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Balancing Inflammation: The Link between Th17 and Regulatory T Cells

CD4(+) T cell compartments in mouse and man are composed of multiple distinct subsets each possessing unique phenotypic and functional characteristics. IL-17-producing CD4(+) T cells (Th17 cells) represent a distinct subset of the CD4(+) T cell lineage. Recent evidence suggests that Th17 cells carry...

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Autores principales: Diller, Maggie L., Kudchadkar, Ragini R., Delman, Keith A., Lawson, David H., Ford, Mandy L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930807/
https://www.ncbi.nlm.nih.gov/pubmed/27413254
http://dx.doi.org/10.1155/2016/6309219
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author Diller, Maggie L.
Kudchadkar, Ragini R.
Delman, Keith A.
Lawson, David H.
Ford, Mandy L.
author_facet Diller, Maggie L.
Kudchadkar, Ragini R.
Delman, Keith A.
Lawson, David H.
Ford, Mandy L.
author_sort Diller, Maggie L.
collection PubMed
description CD4(+) T cell compartments in mouse and man are composed of multiple distinct subsets each possessing unique phenotypic and functional characteristics. IL-17-producing CD4(+) T cells (Th17 cells) represent a distinct subset of the CD4(+) T cell lineage. Recent evidence suggests that Th17 cells carry out effector functions similar to cytotoxic CD8(+) T cells and play an important role in the clearance of extracellular pathogens and fungi. Th17 cell differentiation and function are closely related to the development and function of regulatory T cells (T(REG)). The balance between these two cell populations is essential for immune homeostasis and dysregulation of this balance has been implicated in a variety of inflammatory conditions including autoimmunity, allograft rejection, and tumorigenesis. Emerging evidence reports a significant amount of plasticity between the Th17 and regulatory T cell compartments, and the mechanisms by which these cells communicate and influence each other are just beginning to be understood. In this review, we highlight recent findings detailing the mechanisms driving Th17 and T(REG) plasticity and discuss the biologic consequences of their unique relationship.
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spelling pubmed-49308072016-07-13 Balancing Inflammation: The Link between Th17 and Regulatory T Cells Diller, Maggie L. Kudchadkar, Ragini R. Delman, Keith A. Lawson, David H. Ford, Mandy L. Mediators Inflamm Review Article CD4(+) T cell compartments in mouse and man are composed of multiple distinct subsets each possessing unique phenotypic and functional characteristics. IL-17-producing CD4(+) T cells (Th17 cells) represent a distinct subset of the CD4(+) T cell lineage. Recent evidence suggests that Th17 cells carry out effector functions similar to cytotoxic CD8(+) T cells and play an important role in the clearance of extracellular pathogens and fungi. Th17 cell differentiation and function are closely related to the development and function of regulatory T cells (T(REG)). The balance between these two cell populations is essential for immune homeostasis and dysregulation of this balance has been implicated in a variety of inflammatory conditions including autoimmunity, allograft rejection, and tumorigenesis. Emerging evidence reports a significant amount of plasticity between the Th17 and regulatory T cell compartments, and the mechanisms by which these cells communicate and influence each other are just beginning to be understood. In this review, we highlight recent findings detailing the mechanisms driving Th17 and T(REG) plasticity and discuss the biologic consequences of their unique relationship. Hindawi Publishing Corporation 2016 2016-06-19 /pmc/articles/PMC4930807/ /pubmed/27413254 http://dx.doi.org/10.1155/2016/6309219 Text en Copyright © 2016 Maggie L. Diller et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Diller, Maggie L.
Kudchadkar, Ragini R.
Delman, Keith A.
Lawson, David H.
Ford, Mandy L.
Balancing Inflammation: The Link between Th17 and Regulatory T Cells
title Balancing Inflammation: The Link between Th17 and Regulatory T Cells
title_full Balancing Inflammation: The Link between Th17 and Regulatory T Cells
title_fullStr Balancing Inflammation: The Link between Th17 and Regulatory T Cells
title_full_unstemmed Balancing Inflammation: The Link between Th17 and Regulatory T Cells
title_short Balancing Inflammation: The Link between Th17 and Regulatory T Cells
title_sort balancing inflammation: the link between th17 and regulatory t cells
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930807/
https://www.ncbi.nlm.nih.gov/pubmed/27413254
http://dx.doi.org/10.1155/2016/6309219
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