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Identification of false‐negative and false‐positive diagnoses of lymph node metastases in non‐small cell lung cancer patients staged by integrated (18F‐)fluorodeoxyglucose‐positron emission tomography/computed tomography: A retrospective cohort study

BACKGROUND: The aim of this study was to evaluate the diagnostic accuracy of integrated (18) F‐fluorodeoxyglucose positron emission tomography/computed tomography (FDG‐PET/CT) in hilar and mediastinal lymph node (HMLN) staging of non‐small cell lung cancer (NSCLC), and to investigate potential risk...

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Autores principales: Kaseda, Kaoru, Watanabe, Ken‐ichi, Asakura, Keisuke, Kazama, Akio, Ozawa, Yukihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Australia, Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930968/
https://www.ncbi.nlm.nih.gov/pubmed/27385991
http://dx.doi.org/10.1111/1759-7714.12358
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author Kaseda, Kaoru
Watanabe, Ken‐ichi
Asakura, Keisuke
Kazama, Akio
Ozawa, Yukihiko
author_facet Kaseda, Kaoru
Watanabe, Ken‐ichi
Asakura, Keisuke
Kazama, Akio
Ozawa, Yukihiko
author_sort Kaseda, Kaoru
collection PubMed
description BACKGROUND: The aim of this study was to evaluate the diagnostic accuracy of integrated (18) F‐fluorodeoxyglucose positron emission tomography/computed tomography (FDG‐PET/CT) in hilar and mediastinal lymph node (HMLN) staging of non‐small cell lung cancer (NSCLC), and to investigate potential risk factors for false‐negative and false‐positive HMLN metastases. METHODS: We examined the data of 388 surgically resected NSCLC patients preoperatively staged by integrated FDG‐PET/CT. Risk factors for false‐negative and false‐positive HMLN metastases were analyzed using univariate and multivariate analyses of clinicopathological factors. RESULTS: The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of integrated FDG‐PET/CT in detecting HMLN metastases were 47.4%, 91.0%, 56.3%, 87.7%, and 82.5%, respectively. On multivariate analysis, the maximum standardized uptake value (SUVmax) of the tumor (P = 0.042), adenocarcinoma (P = 0.003), and tumor size (P = 0.017) were risk factors for false‐negative HMLN metastases, and history of lung disease (P = 0.006) and tumor location (central; P = 0.025) were risk factors for false‐positive HMLN metastases. CONCLUSIONS: The present study identified risk factors for false‐negative and false‐positive HMLN metastases in NSCLC patients staged by preoperative integrated FDG‐PET/CT. These findings would be helpful in selecting appropriate candidates for mediastinoscopy or endobronchial ultrasound‐guided transbronchial needle aspiration.
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spelling pubmed-49309682016-07-06 Identification of false‐negative and false‐positive diagnoses of lymph node metastases in non‐small cell lung cancer patients staged by integrated (18F‐)fluorodeoxyglucose‐positron emission tomography/computed tomography: A retrospective cohort study Kaseda, Kaoru Watanabe, Ken‐ichi Asakura, Keisuke Kazama, Akio Ozawa, Yukihiko Thorac Cancer Original Articles BACKGROUND: The aim of this study was to evaluate the diagnostic accuracy of integrated (18) F‐fluorodeoxyglucose positron emission tomography/computed tomography (FDG‐PET/CT) in hilar and mediastinal lymph node (HMLN) staging of non‐small cell lung cancer (NSCLC), and to investigate potential risk factors for false‐negative and false‐positive HMLN metastases. METHODS: We examined the data of 388 surgically resected NSCLC patients preoperatively staged by integrated FDG‐PET/CT. Risk factors for false‐negative and false‐positive HMLN metastases were analyzed using univariate and multivariate analyses of clinicopathological factors. RESULTS: The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of integrated FDG‐PET/CT in detecting HMLN metastases were 47.4%, 91.0%, 56.3%, 87.7%, and 82.5%, respectively. On multivariate analysis, the maximum standardized uptake value (SUVmax) of the tumor (P = 0.042), adenocarcinoma (P = 0.003), and tumor size (P = 0.017) were risk factors for false‐negative HMLN metastases, and history of lung disease (P = 0.006) and tumor location (central; P = 0.025) were risk factors for false‐positive HMLN metastases. CONCLUSIONS: The present study identified risk factors for false‐negative and false‐positive HMLN metastases in NSCLC patients staged by preoperative integrated FDG‐PET/CT. These findings would be helpful in selecting appropriate candidates for mediastinoscopy or endobronchial ultrasound‐guided transbronchial needle aspiration. John Wiley & Sons Australia, Ltd 2016-05-05 2016-07 /pmc/articles/PMC4930968/ /pubmed/27385991 http://dx.doi.org/10.1111/1759-7714.12358 Text en © 2016 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Articles
Kaseda, Kaoru
Watanabe, Ken‐ichi
Asakura, Keisuke
Kazama, Akio
Ozawa, Yukihiko
Identification of false‐negative and false‐positive diagnoses of lymph node metastases in non‐small cell lung cancer patients staged by integrated (18F‐)fluorodeoxyglucose‐positron emission tomography/computed tomography: A retrospective cohort study
title Identification of false‐negative and false‐positive diagnoses of lymph node metastases in non‐small cell lung cancer patients staged by integrated (18F‐)fluorodeoxyglucose‐positron emission tomography/computed tomography: A retrospective cohort study
title_full Identification of false‐negative and false‐positive diagnoses of lymph node metastases in non‐small cell lung cancer patients staged by integrated (18F‐)fluorodeoxyglucose‐positron emission tomography/computed tomography: A retrospective cohort study
title_fullStr Identification of false‐negative and false‐positive diagnoses of lymph node metastases in non‐small cell lung cancer patients staged by integrated (18F‐)fluorodeoxyglucose‐positron emission tomography/computed tomography: A retrospective cohort study
title_full_unstemmed Identification of false‐negative and false‐positive diagnoses of lymph node metastases in non‐small cell lung cancer patients staged by integrated (18F‐)fluorodeoxyglucose‐positron emission tomography/computed tomography: A retrospective cohort study
title_short Identification of false‐negative and false‐positive diagnoses of lymph node metastases in non‐small cell lung cancer patients staged by integrated (18F‐)fluorodeoxyglucose‐positron emission tomography/computed tomography: A retrospective cohort study
title_sort identification of false‐negative and false‐positive diagnoses of lymph node metastases in non‐small cell lung cancer patients staged by integrated (18f‐)fluorodeoxyglucose‐positron emission tomography/computed tomography: a retrospective cohort study
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930968/
https://www.ncbi.nlm.nih.gov/pubmed/27385991
http://dx.doi.org/10.1111/1759-7714.12358
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