Gefitinib for asymptomatic brain metastasis from advanced non‐small cell lung cancer: Report of a favourable outcome

Brain metastasis (BM) is common in patients with non‐small cell lung cancer (NSCLC). Although epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have now been included as standard treatment options for NSCLC harboring EGFR‐activating mutations, only a few prospective reports d...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Wen‐Yang, Liu, Yu‐Tao, Yang, Lin, Zhang, Ye, Liu, Peng, Wang, Yan, Hui, Zhou‐Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Australia, Ltd 2016
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930972/
https://www.ncbi.nlm.nih.gov/pubmed/27385995
http://dx.doi.org/10.1111/1759-7714.12335
_version_ 1782440812109365248
author Liu, Wen‐Yang
Liu, Yu‐Tao
Yang, Lin
Zhang, Ye
Liu, Peng
Wang, Yan
Hui, Zhou‐Guang
author_facet Liu, Wen‐Yang
Liu, Yu‐Tao
Yang, Lin
Zhang, Ye
Liu, Peng
Wang, Yan
Hui, Zhou‐Guang
author_sort Liu, Wen‐Yang
collection PubMed
description Brain metastasis (BM) is common in patients with non‐small cell lung cancer (NSCLC). Although epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have now been included as standard treatment options for NSCLC harboring EGFR‐activating mutations, only a few prospective reports demonstrate the efficacy of these agents in a BM setting. We report a case of a patient with advanced NSCLC, in which oral gefitinib documented a significant antitumor effect on parallel progression of extracranial lesion and BM occurred during chemotherapy.
format Online
Article
Text
id pubmed-4930972
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher John Wiley & Sons Australia, Ltd
record_format MEDLINE/PubMed
spelling pubmed-49309722016-07-06 Gefitinib for asymptomatic brain metastasis from advanced non‐small cell lung cancer: Report of a favourable outcome Liu, Wen‐Yang Liu, Yu‐Tao Yang, Lin Zhang, Ye Liu, Peng Wang, Yan Hui, Zhou‐Guang Thorac Cancer Case Reports Brain metastasis (BM) is common in patients with non‐small cell lung cancer (NSCLC). Although epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have now been included as standard treatment options for NSCLC harboring EGFR‐activating mutations, only a few prospective reports demonstrate the efficacy of these agents in a BM setting. We report a case of a patient with advanced NSCLC, in which oral gefitinib documented a significant antitumor effect on parallel progression of extracranial lesion and BM occurred during chemotherapy. John Wiley & Sons Australia, Ltd 2016-02-02 2016-07 /pmc/articles/PMC4930972/ /pubmed/27385995 http://dx.doi.org/10.1111/1759-7714.12335 Text en © 2016 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Case Reports
Liu, Wen‐Yang
Liu, Yu‐Tao
Yang, Lin
Zhang, Ye
Liu, Peng
Wang, Yan
Hui, Zhou‐Guang
Gefitinib for asymptomatic brain metastasis from advanced non‐small cell lung cancer: Report of a favourable outcome
title Gefitinib for asymptomatic brain metastasis from advanced non‐small cell lung cancer: Report of a favourable outcome
title_full Gefitinib for asymptomatic brain metastasis from advanced non‐small cell lung cancer: Report of a favourable outcome
title_fullStr Gefitinib for asymptomatic brain metastasis from advanced non‐small cell lung cancer: Report of a favourable outcome
title_full_unstemmed Gefitinib for asymptomatic brain metastasis from advanced non‐small cell lung cancer: Report of a favourable outcome
title_short Gefitinib for asymptomatic brain metastasis from advanced non‐small cell lung cancer: Report of a favourable outcome
title_sort gefitinib for asymptomatic brain metastasis from advanced non‐small cell lung cancer: report of a favourable outcome
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930972/
https://www.ncbi.nlm.nih.gov/pubmed/27385995
http://dx.doi.org/10.1111/1759-7714.12335
work_keys_str_mv AT liuwenyang gefitinibforasymptomaticbrainmetastasisfromadvancednonsmallcelllungcancerreportofafavourableoutcome
AT liuyutao gefitinibforasymptomaticbrainmetastasisfromadvancednonsmallcelllungcancerreportofafavourableoutcome
AT yanglin gefitinibforasymptomaticbrainmetastasisfromadvancednonsmallcelllungcancerreportofafavourableoutcome
AT zhangye gefitinibforasymptomaticbrainmetastasisfromadvancednonsmallcelllungcancerreportofafavourableoutcome
AT liupeng gefitinibforasymptomaticbrainmetastasisfromadvancednonsmallcelllungcancerreportofafavourableoutcome
AT wangyan gefitinibforasymptomaticbrainmetastasisfromadvancednonsmallcelllungcancerreportofafavourableoutcome
AT huizhouguang gefitinibforasymptomaticbrainmetastasisfromadvancednonsmallcelllungcancerreportofafavourableoutcome

Ejemplares similares