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A key genetic factor for fucosyllactose utilization affects infant gut microbiota development

Recent studies have demonstrated that gut microbiota development influences infants' health and subsequent host physiology. However, the factors shaping the development of the microbiota remain poorly understood, and the mechanisms through which these factors affect gut metabolite profiles have...

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Autores principales: Matsuki, Takahiro, Yahagi, Kana, Mori, Hiroshi, Matsumoto, Hoshitaka, Hara, Taeko, Tajima, Saya, Ogawa, Eishin, Kodama, Hiroko, Yamamoto, Kazuya, Yamada, Takuji, Matsumoto, Satoshi, Kurokawa, Ken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931012/
https://www.ncbi.nlm.nih.gov/pubmed/27340092
http://dx.doi.org/10.1038/ncomms11939
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author Matsuki, Takahiro
Yahagi, Kana
Mori, Hiroshi
Matsumoto, Hoshitaka
Hara, Taeko
Tajima, Saya
Ogawa, Eishin
Kodama, Hiroko
Yamamoto, Kazuya
Yamada, Takuji
Matsumoto, Satoshi
Kurokawa, Ken
author_facet Matsuki, Takahiro
Yahagi, Kana
Mori, Hiroshi
Matsumoto, Hoshitaka
Hara, Taeko
Tajima, Saya
Ogawa, Eishin
Kodama, Hiroko
Yamamoto, Kazuya
Yamada, Takuji
Matsumoto, Satoshi
Kurokawa, Ken
author_sort Matsuki, Takahiro
collection PubMed
description Recent studies have demonstrated that gut microbiota development influences infants' health and subsequent host physiology. However, the factors shaping the development of the microbiota remain poorly understood, and the mechanisms through which these factors affect gut metabolite profiles have not been extensively investigated. Here we analyse gut microbiota development of 27 infants during the first month of life. We find three distinct clusters that transition towards Bifidobacteriaceae-dominant microbiota. We observe considerable differences in human milk oligosaccharide utilization among infant bifidobacteria. Colonization of fucosyllactose (FL)-utilizing bifidobacteria is associated with altered metabolite profiles and microbiota compositions, which have been previously shown to affect infant health. Genome analysis of infants' bifidobacteria reveals an ABC transporter as a key genetic factor for FL utilization. Thus, the ability of bifidobacteria to utilize FL and the presence of FL in breast milk may affect the development of the gut microbiota in infants, and might ultimately have therapeutic implications.
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spelling pubmed-49310122016-07-12 A key genetic factor for fucosyllactose utilization affects infant gut microbiota development Matsuki, Takahiro Yahagi, Kana Mori, Hiroshi Matsumoto, Hoshitaka Hara, Taeko Tajima, Saya Ogawa, Eishin Kodama, Hiroko Yamamoto, Kazuya Yamada, Takuji Matsumoto, Satoshi Kurokawa, Ken Nat Commun Article Recent studies have demonstrated that gut microbiota development influences infants' health and subsequent host physiology. However, the factors shaping the development of the microbiota remain poorly understood, and the mechanisms through which these factors affect gut metabolite profiles have not been extensively investigated. Here we analyse gut microbiota development of 27 infants during the first month of life. We find three distinct clusters that transition towards Bifidobacteriaceae-dominant microbiota. We observe considerable differences in human milk oligosaccharide utilization among infant bifidobacteria. Colonization of fucosyllactose (FL)-utilizing bifidobacteria is associated with altered metabolite profiles and microbiota compositions, which have been previously shown to affect infant health. Genome analysis of infants' bifidobacteria reveals an ABC transporter as a key genetic factor for FL utilization. Thus, the ability of bifidobacteria to utilize FL and the presence of FL in breast milk may affect the development of the gut microbiota in infants, and might ultimately have therapeutic implications. Nature Publishing Group 2016-06-24 /pmc/articles/PMC4931012/ /pubmed/27340092 http://dx.doi.org/10.1038/ncomms11939 Text en Copyright © 2016, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Matsuki, Takahiro
Yahagi, Kana
Mori, Hiroshi
Matsumoto, Hoshitaka
Hara, Taeko
Tajima, Saya
Ogawa, Eishin
Kodama, Hiroko
Yamamoto, Kazuya
Yamada, Takuji
Matsumoto, Satoshi
Kurokawa, Ken
A key genetic factor for fucosyllactose utilization affects infant gut microbiota development
title A key genetic factor for fucosyllactose utilization affects infant gut microbiota development
title_full A key genetic factor for fucosyllactose utilization affects infant gut microbiota development
title_fullStr A key genetic factor for fucosyllactose utilization affects infant gut microbiota development
title_full_unstemmed A key genetic factor for fucosyllactose utilization affects infant gut microbiota development
title_short A key genetic factor for fucosyllactose utilization affects infant gut microbiota development
title_sort key genetic factor for fucosyllactose utilization affects infant gut microbiota development
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931012/
https://www.ncbi.nlm.nih.gov/pubmed/27340092
http://dx.doi.org/10.1038/ncomms11939
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