Immune Regulation and Antitumor Effect of TIM-1

T cells play an important role in antitumor immunity, and the T cell immunoglobulin domain and the mucin domain protein-1 (TIM-1) on its surface, as a costimulatory molecule, has a strong regulatory effect on T cells. TIM-1 can regulate and enhance type 1 immune response of tumor association. Theref...

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Detalles Bibliográficos
Autores principales: Du, Peng, Xiong, Ruihua, Li, Xiaodong, Jiang, Jingting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931049/
https://www.ncbi.nlm.nih.gov/pubmed/27413764
http://dx.doi.org/10.1155/2016/8605134
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author Du, Peng
Xiong, Ruihua
Li, Xiaodong
Jiang, Jingting
author_facet Du, Peng
Xiong, Ruihua
Li, Xiaodong
Jiang, Jingting
author_sort Du, Peng
collection PubMed
description T cells play an important role in antitumor immunity, and the T cell immunoglobulin domain and the mucin domain protein-1 (TIM-1) on its surface, as a costimulatory molecule, has a strong regulatory effect on T cells. TIM-1 can regulate and enhance type 1 immune response of tumor association. Therefore, TIM-1 costimulatory pathways may be a promising therapeutic target in future tumor immunotherapy. This review describes the immune regulation and antitumor effect of TIM-1.
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spelling pubmed-49310492016-07-13 Immune Regulation and Antitumor Effect of TIM-1 Du, Peng Xiong, Ruihua Li, Xiaodong Jiang, Jingting J Immunol Res Review Article T cells play an important role in antitumor immunity, and the T cell immunoglobulin domain and the mucin domain protein-1 (TIM-1) on its surface, as a costimulatory molecule, has a strong regulatory effect on T cells. TIM-1 can regulate and enhance type 1 immune response of tumor association. Therefore, TIM-1 costimulatory pathways may be a promising therapeutic target in future tumor immunotherapy. This review describes the immune regulation and antitumor effect of TIM-1. Hindawi Publishing Corporation 2016 2016-06-20 /pmc/articles/PMC4931049/ /pubmed/27413764 http://dx.doi.org/10.1155/2016/8605134 Text en Copyright © 2016 Peng Du et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Du, Peng
Xiong, Ruihua
Li, Xiaodong
Jiang, Jingting
Immune Regulation and Antitumor Effect of TIM-1
title Immune Regulation and Antitumor Effect of TIM-1
title_full Immune Regulation and Antitumor Effect of TIM-1
title_fullStr Immune Regulation and Antitumor Effect of TIM-1
title_full_unstemmed Immune Regulation and Antitumor Effect of TIM-1
title_short Immune Regulation and Antitumor Effect of TIM-1
title_sort immune regulation and antitumor effect of tim-1
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931049/
https://www.ncbi.nlm.nih.gov/pubmed/27413764
http://dx.doi.org/10.1155/2016/8605134
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