PGC-1α-Dependent Mitochondrial Adaptation Is Necessary to Sustain IL-2-Induced Activities in Human NK Cells

Human Natural Killer (NK) cells are a specialized heterogeneous subpopulation of lymphocytes involved in antitumor defense reactions. NK cell effector functions are critically dependent on cytokines and metabolic activity. Among various cytokines modulating NK cell function, interleukin-2 (IL-2) can...

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Detalles Bibliográficos
Autores principales: Miranda, Dante, Jara, Claudia, Ibañez, Jorge, Ahumada, Viviana, Acuña-Castillo, Claudio, Martin, Adrian, Córdova, Alexandra, Montoya, Margarita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931085/
https://www.ncbi.nlm.nih.gov/pubmed/27413259
http://dx.doi.org/10.1155/2016/9605253

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