Prosaposin is a regulator of progranulin levels and oligomerization

Progranulin (GRN) loss-of-function mutations leading to progranulin protein (PGRN) haploinsufficiency are prevalent genetic causes of frontotemporal dementia. Reports also indicated PGRN-mediated neuroprotection in models of Alzheimer's and Parkinson's disease; thus, increasing PGRN levels...

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Detalles Bibliográficos
Autores principales: Nicholson, Alexandra M., Finch, NiCole A., Almeida, Marcio, Perkerson, Ralph B., van Blitterswijk, Marka, Wojtas, Aleksandra, Cenik, Basar, Rotondo, Sergio, Inskeep, Venette, Almasy, Laura, Dyer, Thomas, Peralta, Juan, Jun, Goo, Wood, Andrew R., Frayling, Timothy M., Fuchsberger, Christian, Fowler, Sharon, Teslovich, Tanya M., Manning, Alisa K., Kumar, Satish, Curran, Joanne, Lehman, Donna, Abecasis, Goncalo, Duggirala, Ravindranath, Pottier, Cyril, Zahir, Haaris A., Crook, Julia E., Karydas, Anna, Mitic, Laura, Sun, Ying, Dickson, Dennis W., Bu, Guojun, Herz, Joachim, Yu, Gang, Miller, Bruce L., Ferguson, Shawn, Petersen, Ronald C., Graff-Radford, Neill, Blangero, John, Rademakers, Rosa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931318/
https://www.ncbi.nlm.nih.gov/pubmed/27356620
http://dx.doi.org/10.1038/ncomms11992

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