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CXCR2 Inhibition in Human Pluripotent Stem Cells Induces Predominant Differentiation to Mesoderm and Endoderm Through Repression of mTOR, β-Catenin, and hTERT Activities

On the basis of our previous report verifying that chemokine (C-X-C motif) receptor 2 (CXCR2) ligands in human placenta-derived cell conditioned medium (hPCCM) support human pluripotent stem cell (hPSC) propagation without exogenous basic fibroblast growth factor (bFGF), this study was designed to i...

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Detalles Bibliográficos
Autores principales: Jung, Ji-Hye, Kang, Ka-Won, Kim, Jihea, Hong, Soon-Chul, Park, Yong, Kim, Byung Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931345/
https://www.ncbi.nlm.nih.gov/pubmed/27188501
http://dx.doi.org/10.1089/scd.2015.0395