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Effects of microsatellite instability on recurrence patterns and outcomes in colorectal cancers
BACKGROUND: Among colorectal cancers (CRCs), high-frequency microsatellite instability (MSI-H) is associated with a better prognosis, compared with low-frequency MSI or microsatellite stability (MSI-L/MSS). However, it is unclear whether MSI affects the prognosis of recurrent CRCs. METHODS: This stu...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931375/ https://www.ncbi.nlm.nih.gov/pubmed/27228287 http://dx.doi.org/10.1038/bjc.2016.161 |
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author | Kim, Chang Gon Ahn, Joong Bae Jung, Minkyu Beom, Seung Hoon Kim, Chan Kim, Joo Hoon Heo, Su Jin Park, Hyung Soon Kim, Jee Hung Kim, Nam Kyu Min, Byung Soh Kim, Hoguen Koom, Woong Sub Shin, Sang Joon |
author_facet | Kim, Chang Gon Ahn, Joong Bae Jung, Minkyu Beom, Seung Hoon Kim, Chan Kim, Joo Hoon Heo, Su Jin Park, Hyung Soon Kim, Jee Hung Kim, Nam Kyu Min, Byung Soh Kim, Hoguen Koom, Woong Sub Shin, Sang Joon |
author_sort | Kim, Chang Gon |
collection | PubMed |
description | BACKGROUND: Among colorectal cancers (CRCs), high-frequency microsatellite instability (MSI-H) is associated with a better prognosis, compared with low-frequency MSI or microsatellite stability (MSI-L/MSS). However, it is unclear whether MSI affects the prognosis of recurrent CRCs. METHODS: This study included 2940 patients with stage I–III CRC who underwent complete resection. The associations of MSI status with recurrence patterns, disease-free survival (DFS), overall survival from diagnosis to death (OS1), and overall survival from recurrence to death (OS2) were analysed. RESULTS: A total of 261 patients (8.9%) had MSI-H CRC. Patients with MSI-H CRC had better DFS, compared to patients with MSI-L/MSS CRC (hazard ratio (HR): 0.619, P<0.001). High-frequency microsatellite instability CRC was associated with more frequent local recurrence (30.0% vs 12.0%, P=0.032) or peritoneal metastasis (40.0% vs 12.3%, P=0.003), and less frequent lung (10.0% vs 42.5%, P=0.004) or liver metastases (15.0% vs 44.7%, P=0.01). Recurrent MSI-H CRC was associated with worse OS1 (HR: 1.363, P=0.035) and OS2 (HR: 2.667, P<0.001). An analysis of patients with colon cancer yielded similar results. CONCLUSIONS: Recurrence patterns differed between MSI-H CRC and MSI-L/MSS CRC, and recurrent MSI-H CRCs had a worse prognosis. |
format | Online Article Text |
id | pubmed-4931375 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-49313752017-06-28 Effects of microsatellite instability on recurrence patterns and outcomes in colorectal cancers Kim, Chang Gon Ahn, Joong Bae Jung, Minkyu Beom, Seung Hoon Kim, Chan Kim, Joo Hoon Heo, Su Jin Park, Hyung Soon Kim, Jee Hung Kim, Nam Kyu Min, Byung Soh Kim, Hoguen Koom, Woong Sub Shin, Sang Joon Br J Cancer Clinical Study BACKGROUND: Among colorectal cancers (CRCs), high-frequency microsatellite instability (MSI-H) is associated with a better prognosis, compared with low-frequency MSI or microsatellite stability (MSI-L/MSS). However, it is unclear whether MSI affects the prognosis of recurrent CRCs. METHODS: This study included 2940 patients with stage I–III CRC who underwent complete resection. The associations of MSI status with recurrence patterns, disease-free survival (DFS), overall survival from diagnosis to death (OS1), and overall survival from recurrence to death (OS2) were analysed. RESULTS: A total of 261 patients (8.9%) had MSI-H CRC. Patients with MSI-H CRC had better DFS, compared to patients with MSI-L/MSS CRC (hazard ratio (HR): 0.619, P<0.001). High-frequency microsatellite instability CRC was associated with more frequent local recurrence (30.0% vs 12.0%, P=0.032) or peritoneal metastasis (40.0% vs 12.3%, P=0.003), and less frequent lung (10.0% vs 42.5%, P=0.004) or liver metastases (15.0% vs 44.7%, P=0.01). Recurrent MSI-H CRC was associated with worse OS1 (HR: 1.363, P=0.035) and OS2 (HR: 2.667, P<0.001). An analysis of patients with colon cancer yielded similar results. CONCLUSIONS: Recurrence patterns differed between MSI-H CRC and MSI-L/MSS CRC, and recurrent MSI-H CRCs had a worse prognosis. Nature Publishing Group 2016-06-28 2016-05-26 /pmc/articles/PMC4931375/ /pubmed/27228287 http://dx.doi.org/10.1038/bjc.2016.161 Text en Copyright © 2016 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/4.0/ From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/ |
spellingShingle | Clinical Study Kim, Chang Gon Ahn, Joong Bae Jung, Minkyu Beom, Seung Hoon Kim, Chan Kim, Joo Hoon Heo, Su Jin Park, Hyung Soon Kim, Jee Hung Kim, Nam Kyu Min, Byung Soh Kim, Hoguen Koom, Woong Sub Shin, Sang Joon Effects of microsatellite instability on recurrence patterns and outcomes in colorectal cancers |
title | Effects of microsatellite instability on recurrence patterns and outcomes in colorectal cancers |
title_full | Effects of microsatellite instability on recurrence patterns and outcomes in colorectal cancers |
title_fullStr | Effects of microsatellite instability on recurrence patterns and outcomes in colorectal cancers |
title_full_unstemmed | Effects of microsatellite instability on recurrence patterns and outcomes in colorectal cancers |
title_short | Effects of microsatellite instability on recurrence patterns and outcomes in colorectal cancers |
title_sort | effects of microsatellite instability on recurrence patterns and outcomes in colorectal cancers |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931375/ https://www.ncbi.nlm.nih.gov/pubmed/27228287 http://dx.doi.org/10.1038/bjc.2016.161 |
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