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The Role of Autophagy-Related Proteins in Candida albicans Infections
Autophagy plays an important role in maintaining cell homeostasis by providing nutrients during periods of starvation and removing damaged organelles from the cytoplasm. A marker in the autophagic process is the reversible conjugation of LC3, a membrane scaffolding protein, to double membrane autoph...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931385/ https://www.ncbi.nlm.nih.gov/pubmed/27043636 http://dx.doi.org/10.3390/pathogens5020034 |
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author | Tam, Jenny M. Mansour, Michael K. Acharya, Mridu Sokolovska, Anna Timmons, Allison K. Lacy-Hulbert, Adam Vyas, Jatin M. |
author_facet | Tam, Jenny M. Mansour, Michael K. Acharya, Mridu Sokolovska, Anna Timmons, Allison K. Lacy-Hulbert, Adam Vyas, Jatin M. |
author_sort | Tam, Jenny M. |
collection | PubMed |
description | Autophagy plays an important role in maintaining cell homeostasis by providing nutrients during periods of starvation and removing damaged organelles from the cytoplasm. A marker in the autophagic process is the reversible conjugation of LC3, a membrane scaffolding protein, to double membrane autophagosomes. Recently, a role for LC3 in the elimination of pathogenic bacteria and fungi, including Candida albicans (C. albicans), was demonstrated, but these organisms reside in single membrane phagosomes. This process is distinct from autophagy and is termed LC3-associated phagocytosis (LAP). This review will detail the hallmarks of LAP that distinguish it from classical autophagy and review the role of autophagy proteins in host response to C. albicans and other pathogenic fungi. |
format | Online Article Text |
id | pubmed-4931385 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-49313852016-07-08 The Role of Autophagy-Related Proteins in Candida albicans Infections Tam, Jenny M. Mansour, Michael K. Acharya, Mridu Sokolovska, Anna Timmons, Allison K. Lacy-Hulbert, Adam Vyas, Jatin M. Pathogens Review Autophagy plays an important role in maintaining cell homeostasis by providing nutrients during periods of starvation and removing damaged organelles from the cytoplasm. A marker in the autophagic process is the reversible conjugation of LC3, a membrane scaffolding protein, to double membrane autophagosomes. Recently, a role for LC3 in the elimination of pathogenic bacteria and fungi, including Candida albicans (C. albicans), was demonstrated, but these organisms reside in single membrane phagosomes. This process is distinct from autophagy and is termed LC3-associated phagocytosis (LAP). This review will detail the hallmarks of LAP that distinguish it from classical autophagy and review the role of autophagy proteins in host response to C. albicans and other pathogenic fungi. MDPI 2016-03-29 /pmc/articles/PMC4931385/ /pubmed/27043636 http://dx.doi.org/10.3390/pathogens5020034 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Tam, Jenny M. Mansour, Michael K. Acharya, Mridu Sokolovska, Anna Timmons, Allison K. Lacy-Hulbert, Adam Vyas, Jatin M. The Role of Autophagy-Related Proteins in Candida albicans Infections |
title | The Role of Autophagy-Related Proteins in Candida albicans Infections |
title_full | The Role of Autophagy-Related Proteins in Candida albicans Infections |
title_fullStr | The Role of Autophagy-Related Proteins in Candida albicans Infections |
title_full_unstemmed | The Role of Autophagy-Related Proteins in Candida albicans Infections |
title_short | The Role of Autophagy-Related Proteins in Candida albicans Infections |
title_sort | role of autophagy-related proteins in candida albicans infections |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931385/ https://www.ncbi.nlm.nih.gov/pubmed/27043636 http://dx.doi.org/10.3390/pathogens5020034 |
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