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The Role of Autophagy-Related Proteins in Candida albicans Infections

Autophagy plays an important role in maintaining cell homeostasis by providing nutrients during periods of starvation and removing damaged organelles from the cytoplasm. A marker in the autophagic process is the reversible conjugation of LC3, a membrane scaffolding protein, to double membrane autoph...

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Autores principales: Tam, Jenny M., Mansour, Michael K., Acharya, Mridu, Sokolovska, Anna, Timmons, Allison K., Lacy-Hulbert, Adam, Vyas, Jatin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931385/
https://www.ncbi.nlm.nih.gov/pubmed/27043636
http://dx.doi.org/10.3390/pathogens5020034
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author Tam, Jenny M.
Mansour, Michael K.
Acharya, Mridu
Sokolovska, Anna
Timmons, Allison K.
Lacy-Hulbert, Adam
Vyas, Jatin M.
author_facet Tam, Jenny M.
Mansour, Michael K.
Acharya, Mridu
Sokolovska, Anna
Timmons, Allison K.
Lacy-Hulbert, Adam
Vyas, Jatin M.
author_sort Tam, Jenny M.
collection PubMed
description Autophagy plays an important role in maintaining cell homeostasis by providing nutrients during periods of starvation and removing damaged organelles from the cytoplasm. A marker in the autophagic process is the reversible conjugation of LC3, a membrane scaffolding protein, to double membrane autophagosomes. Recently, a role for LC3 in the elimination of pathogenic bacteria and fungi, including Candida albicans (C. albicans), was demonstrated, but these organisms reside in single membrane phagosomes. This process is distinct from autophagy and is termed LC3-associated phagocytosis (LAP). This review will detail the hallmarks of LAP that distinguish it from classical autophagy and review the role of autophagy proteins in host response to C. albicans and other pathogenic fungi.
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spelling pubmed-49313852016-07-08 The Role of Autophagy-Related Proteins in Candida albicans Infections Tam, Jenny M. Mansour, Michael K. Acharya, Mridu Sokolovska, Anna Timmons, Allison K. Lacy-Hulbert, Adam Vyas, Jatin M. Pathogens Review Autophagy plays an important role in maintaining cell homeostasis by providing nutrients during periods of starvation and removing damaged organelles from the cytoplasm. A marker in the autophagic process is the reversible conjugation of LC3, a membrane scaffolding protein, to double membrane autophagosomes. Recently, a role for LC3 in the elimination of pathogenic bacteria and fungi, including Candida albicans (C. albicans), was demonstrated, but these organisms reside in single membrane phagosomes. This process is distinct from autophagy and is termed LC3-associated phagocytosis (LAP). This review will detail the hallmarks of LAP that distinguish it from classical autophagy and review the role of autophagy proteins in host response to C. albicans and other pathogenic fungi. MDPI 2016-03-29 /pmc/articles/PMC4931385/ /pubmed/27043636 http://dx.doi.org/10.3390/pathogens5020034 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tam, Jenny M.
Mansour, Michael K.
Acharya, Mridu
Sokolovska, Anna
Timmons, Allison K.
Lacy-Hulbert, Adam
Vyas, Jatin M.
The Role of Autophagy-Related Proteins in Candida albicans Infections
title The Role of Autophagy-Related Proteins in Candida albicans Infections
title_full The Role of Autophagy-Related Proteins in Candida albicans Infections
title_fullStr The Role of Autophagy-Related Proteins in Candida albicans Infections
title_full_unstemmed The Role of Autophagy-Related Proteins in Candida albicans Infections
title_short The Role of Autophagy-Related Proteins in Candida albicans Infections
title_sort role of autophagy-related proteins in candida albicans infections
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931385/
https://www.ncbi.nlm.nih.gov/pubmed/27043636
http://dx.doi.org/10.3390/pathogens5020034
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