Limitations and Prospects for Diffusion-Weighted MRI of the Prostate

Diffusion-weighted imaging (DWI) is the most effective component of the modern multi-parametric magnetic resonance imaging (mpMRI) scan for prostate pathology. DWI provides the strongest prediction of cancer volume, and the apparent diffusion coefficient (ADC) correlates moderately with Gleason grad...

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Detalles Bibliográficos
Autores principales: Bourne, Roger, Panagiotaki, Eleftheria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931416/
https://www.ncbi.nlm.nih.gov/pubmed/27240408
http://dx.doi.org/10.3390/diagnostics6020021
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author Bourne, Roger
Panagiotaki, Eleftheria
author_facet Bourne, Roger
Panagiotaki, Eleftheria
author_sort Bourne, Roger
collection PubMed
description Diffusion-weighted imaging (DWI) is the most effective component of the modern multi-parametric magnetic resonance imaging (mpMRI) scan for prostate pathology. DWI provides the strongest prediction of cancer volume, and the apparent diffusion coefficient (ADC) correlates moderately with Gleason grade. Notwithstanding the demonstrated cancer assessment value of DWI, the standard measurement and signal analysis methods are based on a model of water diffusion dynamics that is well known to be invalid in human tissue. This review describes the biophysical limitations of the DWI component of the current standard mpMRI protocol and the potential for significantly improved cancer assessment performance based on more sophisticated measurement and signal modeling techniques.
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spelling pubmed-49314162016-07-08 Limitations and Prospects for Diffusion-Weighted MRI of the Prostate Bourne, Roger Panagiotaki, Eleftheria Diagnostics (Basel) Review Diffusion-weighted imaging (DWI) is the most effective component of the modern multi-parametric magnetic resonance imaging (mpMRI) scan for prostate pathology. DWI provides the strongest prediction of cancer volume, and the apparent diffusion coefficient (ADC) correlates moderately with Gleason grade. Notwithstanding the demonstrated cancer assessment value of DWI, the standard measurement and signal analysis methods are based on a model of water diffusion dynamics that is well known to be invalid in human tissue. This review describes the biophysical limitations of the DWI component of the current standard mpMRI protocol and the potential for significantly improved cancer assessment performance based on more sophisticated measurement and signal modeling techniques. MDPI 2016-05-27 /pmc/articles/PMC4931416/ /pubmed/27240408 http://dx.doi.org/10.3390/diagnostics6020021 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bourne, Roger
Panagiotaki, Eleftheria
Limitations and Prospects for Diffusion-Weighted MRI of the Prostate
title Limitations and Prospects for Diffusion-Weighted MRI of the Prostate
title_full Limitations and Prospects for Diffusion-Weighted MRI of the Prostate
title_fullStr Limitations and Prospects for Diffusion-Weighted MRI of the Prostate
title_full_unstemmed Limitations and Prospects for Diffusion-Weighted MRI of the Prostate
title_short Limitations and Prospects for Diffusion-Weighted MRI of the Prostate
title_sort limitations and prospects for diffusion-weighted mri of the prostate
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931416/
https://www.ncbi.nlm.nih.gov/pubmed/27240408
http://dx.doi.org/10.3390/diagnostics6020021
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