tRNA Core Hypothesis for the Transition from the RNA World to the Ribonucleoprotein World

Herein we present the tRNA core hypothesis, which emphasizes the central role of tRNAs molecules in the origin and evolution of fundamental biological processes. tRNAs gave origin to the first genes (mRNA) and the peptidyl transferase center (rRNA), proto-tRNAs were at the core of a proto-translatio...

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Detalles Bibliográficos
Autores principales: de Farias, Savio T., Rêgo, Thais G., José, Marco V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931452/
https://www.ncbi.nlm.nih.gov/pubmed/27023615
http://dx.doi.org/10.3390/life6020015
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author de Farias, Savio T.
Rêgo, Thais G.
José, Marco V.
author_facet de Farias, Savio T.
Rêgo, Thais G.
José, Marco V.
author_sort de Farias, Savio T.
collection PubMed
description Herein we present the tRNA core hypothesis, which emphasizes the central role of tRNAs molecules in the origin and evolution of fundamental biological processes. tRNAs gave origin to the first genes (mRNA) and the peptidyl transferase center (rRNA), proto-tRNAs were at the core of a proto-translation system, and the anticodon and operational codes then arose in tRNAs molecules. Metabolic pathways emerged from evolutionary pressures of the decoding systems. The transitions from the RNA world to the ribonucleoprotein world to modern biological systems were driven by three kinds of tRNAs transitions, to wit, tRNAs leading to both mRNA and rRNA.
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spelling pubmed-49314522016-07-08 tRNA Core Hypothesis for the Transition from the RNA World to the Ribonucleoprotein World de Farias, Savio T. Rêgo, Thais G. José, Marco V. Life (Basel) Article Herein we present the tRNA core hypothesis, which emphasizes the central role of tRNAs molecules in the origin and evolution of fundamental biological processes. tRNAs gave origin to the first genes (mRNA) and the peptidyl transferase center (rRNA), proto-tRNAs were at the core of a proto-translation system, and the anticodon and operational codes then arose in tRNAs molecules. Metabolic pathways emerged from evolutionary pressures of the decoding systems. The transitions from the RNA world to the ribonucleoprotein world to modern biological systems were driven by three kinds of tRNAs transitions, to wit, tRNAs leading to both mRNA and rRNA. MDPI 2016-03-23 /pmc/articles/PMC4931452/ /pubmed/27023615 http://dx.doi.org/10.3390/life6020015 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
de Farias, Savio T.
Rêgo, Thais G.
José, Marco V.
tRNA Core Hypothesis for the Transition from the RNA World to the Ribonucleoprotein World
title tRNA Core Hypothesis for the Transition from the RNA World to the Ribonucleoprotein World
title_full tRNA Core Hypothesis for the Transition from the RNA World to the Ribonucleoprotein World
title_fullStr tRNA Core Hypothesis for the Transition from the RNA World to the Ribonucleoprotein World
title_full_unstemmed tRNA Core Hypothesis for the Transition from the RNA World to the Ribonucleoprotein World
title_short tRNA Core Hypothesis for the Transition from the RNA World to the Ribonucleoprotein World
title_sort trna core hypothesis for the transition from the rna world to the ribonucleoprotein world
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931452/
https://www.ncbi.nlm.nih.gov/pubmed/27023615
http://dx.doi.org/10.3390/life6020015
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