Monoclonal antibody with conformational specificity for a toxic conformer of amyloid β42 and its application toward the Alzheimer’s disease diagnosis

Amyloid β-protein (Aβ42) oligomerization is an early event in Alzheimer’s disease (AD). Current diagnostic methods using sequence-specific antibodies against less toxic fibrillar and monomeric Aβ42 run the risk of overdiagnosis. Hence, conformation-specific antibodies against neurotoxic Aβ42 oligome...

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Detalles Bibliográficos
Autores principales: Murakami, Kazuma, Tokuda, Maki, Suzuki, Takashi, Irie, Yumi, Hanaki, Mizuho, Izuo, Naotaka, Monobe, Yoko, Akagi, Ken-ichi, Ishii, Ryotaro, Tatebe, Harutsugu, Tokuda, Takahiko, Maeda, Masahiro, Kume, Toshiaki, Shimizu, Takahiko, Irie, Kazuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931470/
https://www.ncbi.nlm.nih.gov/pubmed/27374357
http://dx.doi.org/10.1038/srep29038

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931470/
https://www.ncbi.nlm.nih.gov/pubmed/27374357
http://dx.doi.org/10.1038/srep29038

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