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Propofol-Induced Neurotoxicity in the Fetal Animal Brain and Developments in Modifying These Effects—An Updated Review of Propofol Fetal Exposure in Laboratory Animal Studies

In the past twenty years, evidence of neurotoxicity in the developing brain in animal studies from exposure to several general anesthetics has been accumulating. Propofol, a commonly used general anesthetic medication, administered during synaptogenesis, may trigger widespread apoptotic neurodegener...

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Detalles Bibliográficos
Autores principales: Xiong, Ming, Zhang, Li, Li, Jing, Eloy, Jean, Ye, Jiang Hong, Bekker, Alex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931488/
https://www.ncbi.nlm.nih.gov/pubmed/27043637
http://dx.doi.org/10.3390/brainsci6020011
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author Xiong, Ming
Zhang, Li
Li, Jing
Eloy, Jean
Ye, Jiang Hong
Bekker, Alex
author_facet Xiong, Ming
Zhang, Li
Li, Jing
Eloy, Jean
Ye, Jiang Hong
Bekker, Alex
author_sort Xiong, Ming
collection PubMed
description In the past twenty years, evidence of neurotoxicity in the developing brain in animal studies from exposure to several general anesthetics has been accumulating. Propofol, a commonly used general anesthetic medication, administered during synaptogenesis, may trigger widespread apoptotic neurodegeneration in the developing brain and long-term neurobehavioral disturbances in both rodents and non-human primates. Despite the growing evidence of the potential neurotoxicity of different anesthetic agents in animal studies, there is no concrete evidence that humans may be similarly affected. However, given the growing evidence of the neurotoxic effects of anesthetics in laboratory studies, it is prudent to further investigate the mechanisms causing these effects and potential ways to mitigate them. Here, we review multiple studies that investigate the effects of in utero propofol exposure and the developmental agents that may modify these deleterious effects.
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spelling pubmed-49314882016-07-08 Propofol-Induced Neurotoxicity in the Fetal Animal Brain and Developments in Modifying These Effects—An Updated Review of Propofol Fetal Exposure in Laboratory Animal Studies Xiong, Ming Zhang, Li Li, Jing Eloy, Jean Ye, Jiang Hong Bekker, Alex Brain Sci Review In the past twenty years, evidence of neurotoxicity in the developing brain in animal studies from exposure to several general anesthetics has been accumulating. Propofol, a commonly used general anesthetic medication, administered during synaptogenesis, may trigger widespread apoptotic neurodegeneration in the developing brain and long-term neurobehavioral disturbances in both rodents and non-human primates. Despite the growing evidence of the potential neurotoxicity of different anesthetic agents in animal studies, there is no concrete evidence that humans may be similarly affected. However, given the growing evidence of the neurotoxic effects of anesthetics in laboratory studies, it is prudent to further investigate the mechanisms causing these effects and potential ways to mitigate them. Here, we review multiple studies that investigate the effects of in utero propofol exposure and the developmental agents that may modify these deleterious effects. MDPI 2016-03-28 /pmc/articles/PMC4931488/ /pubmed/27043637 http://dx.doi.org/10.3390/brainsci6020011 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Xiong, Ming
Zhang, Li
Li, Jing
Eloy, Jean
Ye, Jiang Hong
Bekker, Alex
Propofol-Induced Neurotoxicity in the Fetal Animal Brain and Developments in Modifying These Effects—An Updated Review of Propofol Fetal Exposure in Laboratory Animal Studies
title Propofol-Induced Neurotoxicity in the Fetal Animal Brain and Developments in Modifying These Effects—An Updated Review of Propofol Fetal Exposure in Laboratory Animal Studies
title_full Propofol-Induced Neurotoxicity in the Fetal Animal Brain and Developments in Modifying These Effects—An Updated Review of Propofol Fetal Exposure in Laboratory Animal Studies
title_fullStr Propofol-Induced Neurotoxicity in the Fetal Animal Brain and Developments in Modifying These Effects—An Updated Review of Propofol Fetal Exposure in Laboratory Animal Studies
title_full_unstemmed Propofol-Induced Neurotoxicity in the Fetal Animal Brain and Developments in Modifying These Effects—An Updated Review of Propofol Fetal Exposure in Laboratory Animal Studies
title_short Propofol-Induced Neurotoxicity in the Fetal Animal Brain and Developments in Modifying These Effects—An Updated Review of Propofol Fetal Exposure in Laboratory Animal Studies
title_sort propofol-induced neurotoxicity in the fetal animal brain and developments in modifying these effects—an updated review of propofol fetal exposure in laboratory animal studies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931488/
https://www.ncbi.nlm.nih.gov/pubmed/27043637
http://dx.doi.org/10.3390/brainsci6020011
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